Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$123K - $172K *
Join our dynamic team to tackle real challenges in SaaS management, enhancing IT and Security ecosystems. Collaborate with talented professionals to build impactful software while leveraging AI for ef...
1 week ago
$120K - $145K *
Lead cross-functional teams to develop and execute a strategic product roadmap, integrating market insights and performance metrics to drive customer-centric solutions in the diagnostics and genomics...
3 weeks ago
Customer Development Specialist - The Carolinas
$68K - $93K *
Drive sales growth by developing relationships with veterinary practices, utilizing digital marketing and CRM tools to enhance customer engagement and achieve sales targets in a dynamic inside sales e...
1 week ago
$100K - $115K *
Champion digital success by advising dealers on marketing strategies, analyzing performance metrics, and providing consultative services to enhance sales and service operations. Drive measurable impro...
2 weeks ago
Senior Product Manager - Identity Inventory, Correlation and Graph
$125K - $150K *
Champion the evolution of identity security by leading product management for our core identity graph and correlation services, ensuring seamless integration and access control across platforms while...
4 weeks ago
System Implementation Specialist
$75K - $120K *
Advance your career by implementing innovative SaaS solutions, configuring custom workflows, and driving system integration projects. Collaborate with a dynamic team to tackle complex challenges and d...
4 weeks ago
Associate Medical Director- Rare Neuro
$175K - $200K *
Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...
Reposted 3 days ago
Cyber Security Specialist Lead
$96K - $133K *
Support our cyber defense initiatives by leading incident response efforts, analyzing security events, and optimizing detection capabilities to enhance network security and protect sensitive data...
3 weeks ago
Clinical Genomics Advanced Practice Provider
$110K - $130K *
Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...
1 week ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
Yesterday
$160K - $200K *
Elevate patient care by administering anesthesia and collaborating with healthcare teams. Develop pre-anesthetic plans, monitor patients, and ensure safety during procedures while communicating effect...
6 days ago
$160K - $200K *
Administer anesthesia and sedation for diverse procedures, develop pre-anesthetic plans, collaborate with healthcare teams, and monitor patient responses to ensure optimal care and safety throughout s...
6 days ago
$170K - $200K *
Unlock your potential in a dynamic anesthesia role, collaborating with a skilled team to deliver exceptional patient care. Enjoy a balanced schedule with generous time off while managing diverse surgi...
2 weeks ago
Legal Technology Consulting Director - Discovery and Data Management
$150K - $180K *
Lead and manage complex eDiscovery projects for Fortune 500 clients, enhancing their legal hold and discovery processes. Collaborate with teams to implement innovative solutions and maintain strong cl...
Reposted 3 weeks ago
Strategic Account Executive - Healthcare
$133K - $177K *
Join a team that's transforming healthcare by driving strategic account growth and solving complex identity challenges. Collaborate with cross-functional teams to deliver measurable outcomes and enhan...
1 week ago
$90K - $110K *
Advance your career by delivering critical cost estimates for federal programs. Collaborate with a dynamic team to enhance national security through effective budgeting and analysis of advanced commun...
1 week ago
USCAN Services Finance Analyst - FP&A Operations
$105K - $158K *
Optimize financial performance by partnering with operations to enhance cost efficiency and profitability. Drive strategic investment decisions and support budgeting processes while ensuring alignment...
1 week ago
$111K - $167K *
Empower your career by leading IT systems development, implementation, and maintenance. Oversee complex networks, ensure security, and drive automation, all while collaborating to enhance operational...
Reposted 3 weeks ago
Associate General Counsel, Legal (US)
$200K - $398K *
Drive impactful legal strategies in a global clinical research environment, guiding senior leadership on complex regulatory and compliance matters while fostering innovation and risk management across...
3 weeks ago
Professional Services Manager (HEDIS & Risk)
$95K - $115K *
Lead the charge in managing client engagements within healthcare, translating complex data and workflows into actionable solutions. Drive customer success by fostering relationships and guiding client...
Yesterday
Senior Manager, Precision Medicine - Clinical Diagnostics
$150K - $245K *
Drive the execution of companion diagnostics strategy, managing cross-functional teams and partnerships to ensure successful assay development and regulatory compliance, ultimately enhancing patient o...
2 weeks ago
Account Specialists (St. Paul, MN)
$160K - $192K *
Shape the future of healthcare by driving commercial performance and building strong relationships with providers. Engage in product launches and optimize patient access to innovative therapies across...
1 week ago
Principal Architect, Healthcare
$165K - $243K *
Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...
1 week ago
Field Reimbursement Manager, Southeast - Skeletal Dysplasia,
$185K - $235K *
Optimize family access and reimbursement strategies in a hybrid role, collaborating with healthcare providers and families. Leverage your expertise to navigate complex pathways, ensuring compliance an...
2 days ago
$110K - $130K *
Join us in shaping the future of maternal and newborn health by leading innovative strategies in commodity financing and procurement. Drive impactful change at global and country levels to ensure esse...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.