Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...
2 weeks ago
Director - Product Management, LillyDirect, EMEA
$163K - $297K *
Champion the development and execution of innovative digital product strategies across EMEA, enhancing consumer experiences and driving key performance indicators in a high-growth e-commerce environme...
1 week ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- West
$76K - $114K *
Grow your career with a dynamic role focused on driving sales and clinical engagement in Electrophysiology Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance...
2 weeks ago
$100K - $120K *
Unlock potential by designing and optimizing data pipelines, ensuring seamless integration and delivery of business-ready datasets. Collaborate across cloud and on-premises environments to enhance dat...
4 weeks ago
$100K - $120K *
Support public health initiatives by managing community grant portfolios, providing technical assistance, and enhancing local coalitions' capacity to prevent youth substance use. Collaborate with stak...
Yesterday
South Central, Key Account Manager, Cattle
$80K - $95K *
Unlock potential by driving sales growth and fostering customer relationships in the cattle healthcare sector. Collaborate with a dynamic team to achieve strategic objectives and enhance brand presenc...
2 weeks ago
Market Development Director (Health Systems)
$125K - $150K *
Drive enterprise growth by engaging top health system executives, transforming clinical outcomes through innovative solutions, and building strategic partnerships to expand market presence and adoptio...
4 weeks ago
$115K - $130K *
Champion innovative design solutions by integrating AI into user experiences, driving product evolution through collaboration with cross-functional teams, and enhancing customer engagement across dive...
Yesterday
Case Manager - Registered Nurse - South Region
$60K - $129K *
Partner with us to enhance health outcomes through a comprehensive, collaborative case management approach, engaging with clients and healthcare providers to optimize care plans and ensure quality ser...
Reposted 1 week ago
$175K - $215K *
Launch impactful product initiatives by bridging engineering and design while driving user-centered solutions and leveraging AI tools for enhanced workflows in a high-growth environment...
Reposted 3 weeks ago
$73K - $91K *
Transform healthcare by providing compassionate, patient-centered nursing care. Join a dedicated team where your skills and professionalism will make a meaningful impact in a fast-paced environment fo...
2 weeks ago
Senior Principal Solutions Architect (Federal Civilian Growth)
$200K - $250K *
Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...
Reposted 2 days ago
Group Account Supervisor - Healthcare and Pharmaceutical Advertising
$100K - $139K *
Lead a dynamic account team to drive strategic growth and client relationships. Oversee financial management and tactical execution while fostering team development and ensuring high-level client sati...
2 weeks ago
Senior Consultant - HHS Collaboratives
$90K - $150K *
Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...
3 days ago
Senior Business Development Manager, Medical Channel - Northeast
$100K - $115K *
Engage with healthcare professionals to drive growth in the physician-dispensed skincare market. This role involves building relationships, managing accounts, and delivering training to ensure product...
2 weeks ago
Strategic ABA Practice Partner
$100K - $120K *
Unlock potential by partnering with ABA practice owners to enhance operations, drive growth, and improve performance. Collaborate closely with providers to navigate challenges and implement strategic...
3 days ago
Senior Principal Symplicity Territory Manager - North Dakota/South Dakota
$105K *
Help us drive patient engagement and therapy adoption for innovative renal denervation technology. This remote role focuses on territory development, account activation, and collaboration with healthc...
Reposted 2 days ago
Director, Technical Products and Operations
$200K - $235K *
Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...
Reposted 1 week ago
Vice President, Integrated Medicines Business — East
$300K - $500K+*
Join a dynamic team as a senior leader driving portfolio performance across the eastern U.S. Oversee regional execution, manage a team of directors, and collaborate on national strategies to enhance b...
Today
Associate Director, Business Improvement
$130K - $160K *
Reimagine business improvement strategies as a senior contributor, leading high-impact initiatives across functions. Drive alignment, governance, and measurable outcomes while influencing stakeholders...
2 weeks ago
21GRAMS- Associate Creative Director, Copy
$160K - $180K *
Unlock potential by leading creative engagements across healthcare accounts. Drive innovative campaigns, mentor teams, and manage client relationships while delivering impactful narratives that resona...
3 days ago
Clinical Research Associate- Wound Care Experience Required
$95K - $120K *
Elevate clinical trial success by providing expert oversight and guidance. Collaborate with cross-functional teams to ensure compliance, quality, and timely execution of monitoring activities while fo...
2 weeks ago
$150K - $180K *
Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...
6 days ago
$250K - $300K *
Champion innovation by leading the engineering org, guiding tech strategy, and enhancing collaboration that leverages AI to boost efficiency and quality in software development...
1 month ago
$92K - $167K *
Unlock potential by developing and maintaining scalable applications, integrating new technologies, and participating in Agile methodologies to enhance product features and client solutions...
Reposted today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.