Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Database Administrator (Fully Remote)
$95K - $115K *
Shape the future of database management by leading the architecture, migration, and security of relational and NoSQL databases in cloud and on-premises environments, ensuring optimal performance and c...
Today
$80K - $95K *
Drive financial accuracy and compliance as a Senior Accountant. Lead month-end close, maintain internal controls, and support auditors while refining processes. Ideal for proactive self-starters seeki...
Reposted 4 weeks ago
$66K - $99K *
Elevate care standards by providing individualized nursing support to residents. Collaborate with families and interdisciplinary teams to ensure effective health maintenance and treatment, while leadi...
2 weeks ago
Nurse Practitioner - National After-Hours Team - Full Time - IA and MO Licensed
$95K - $115K *
Take ownership of after-hours telephonic care for aging residents, providing critical support and clinical direction across multiple states. Deliver high-quality, compassionate care while managing hig...
2 days ago
$163K - $245K *
Shape security architecture by designing robust frameworks across various tech domains. Collaborate with cross-functional teams to ensure comprehensive cybersecurity solutions aligned with business go...
Reposted 3 weeks ago
Market Development Director (Health Systems - Southeast)
$125K - $150K *
Join a team that's transforming healthcare by driving enterprise sales and partnerships with leading health systems. Leverage your expertise to educate executives on innovative solutions that enhance...
2 days ago
$85K - $100K *
Analyze performance metrics to empower ACOs in Value-Based Care programs. Collaborate with teams to provide actionable insights, track KPIs, and optimize risk scores, driving data-driven decisions for...
Today
Senior Advisor, Clinical Pharmacology
$153K - $268K *
Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...
1 week ago
Associate Director, Project Management
$117K - $189K *
Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...
Reposted 3 days ago
$100K - $120K *
Unlock potential by delivering expert pharmacy consulting and clinical services. Collaborate with a dedicated team to ensure medication safety, educate patients, and mentor pharmacy staff in a support...
3 weeks ago
$100K - $120K *
Inspire healthcare excellence by providing expert pharmacy consulting, educating patients on medication use, and ensuring safety through compliance. Collaborate with a dedicated team to deliver clinic...
3 weeks ago
$100K - $120K *
Drive patient-centered pharmacy services by providing expert consultations, educating on medication use, and ensuring safety through compliance. Mentor team members while delivering clinical healthcar...
3 weeks ago
$202K - $257K *
Empower growth by identifying opportunities and aligning technical strategies with customer goals. Lead solution discussions with executives, drive innovation, and mentor teams to enhance knowledge an...
3 weeks ago
Clinical Sciences Director, Oncology
$211K - $285K *
Lead the charge in late-phase oncology clinical development, collaborating across teams to design and deliver impactful results. Provide expertise in clinical trial science and data analysis, ensuring...
Today
$100K - $300K *
Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...
3 days ago
Customer Development Specialist - Great Lakes (MI)
$68K - $93K *
Empower veterinary practices by driving sales through relationship building, strategic planning, and digital engagement. Utilize CRM tools to enhance customer experiences and achieve sales targets in...
1 week ago
$150K - $175K *
Shape exceptional user experiences by leading design for a unified legal platform. Drive user-centered solutions through research, collaboration, and design leadership to meet the complex needs of leg...
Reposted 4 weeks ago
System Manager of Enterprise Resilience
$110K - $130K *
Lead the charge in enhancing enterprise-wide Business Continuity programs, ensuring critical healthcare services remain uninterrupted. Collaborate across teams to strengthen resilience and deliver mea...
1 week ago
Director, Health Plans (Account Executive)
$120K - $135K *
Support the growth of health plan accounts by fostering client relationships, analyzing data, and driving retention in a fast-paced, independent role. Leverage strong communication and analytical skil...
4 weeks ago
$90K - $95K *
Drive the successful adoption of advanced hearing solutions by providing expert clinical support and education to healthcare professionals. Collaborate closely with cross-functional teams to enhance p...
4 weeks ago
Lead AI Engineer with semantic web tech
$150K - $180K *
Shape the future of semantic technologies by guiding teams in architecting scalable data solutions. Collaborate across functions to define ontologies and drive enterprise-wide data strategy while ment...
1 month ago
$165K - $190K *
Manage customer outcomes from onboarding through to renewal, driving success via strategic engagement and value realization. Be the go-to advisor ensuring alignment with business goals and optimizing...
Reposted 2 weeks ago
Regional Sales Director - Upstate NY
$180K - $215K *
Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...
1 week ago
$110K - $130K *
Shape the future of healthcare by leading complex implementations across provider and payor organizations. Drive project success through collaboration, strategic planning, and innovative solutions whi...
6 days ago
Associate Director, Social Media
$90K - $115K *
Elevate your career by leading innovative social media programs that connect healthcare clients with their audiences. Drive strategic content development and manage cross-functional teams to ensure im...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.