Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Account Specialist (Madison, WI)
$160K - $192K *
Join a dynamic team to drive commercial performance and enhance patient access through strong relationships with healthcare providers, executing strategic business plans in a pivotal role focused on i...
1 week ago
Associate Director - Medical Science Liaison, Oncology (GI/Thoracic Focus) - Upper Midwest
$156K - $250K *
Lead the charge in scientific dialogue with key healthcare professionals, providing critical insights and support within your therapeutic area. Utilize your expertise to enhance patient outcomes and f...
Reposted 2 days ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
Senior Director, Delivery Excellence
$207K - $277K *
Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...
3 weeks ago
Senior Network Development Contractor
$100K - $120K *
Drive network expansion by engaging providers and negotiating contracts to enhance Medicare services. Collaborate with a remote team to ensure network adequacy and build strong relationships with heal...
2 weeks ago
VP, Account Management - Carolinas (NC/SC)
$164K - $305K *
Join a team that's redefining account management by driving growth and retention for complex health systems. Build strategic relationships with C-suite executives and lead cross-functional teams to de...
1 week ago
$180K - $220K *
Join a team that's paving the way for innovative product and engineering solutions. As a Senior Corporate Counsel, you'll provide essential legal guidance on AI, payments, and privacy, ensuring compli...
Reposted 4 weeks ago
$80K - $100K *
Lead strategic growth and satisfaction for key national accounts in the collision repair industry. Drive collaboration, enhance relationships, and ensure performance metrics are met while advocating f...
4 weeks ago
Senior Growth Consultant - US Remote
$110K - $130K *
Drive growth and brand engagement strategies for franchisees, focusing on retention, optimization, and measurable outcomes. Collaborate with leadership to enhance performance and deliver exceptional b...
3 weeks ago
$160K - $192K *
Lead the charge in driving commercial performance by engaging healthcare providers, building relationships, and executing territory business plans to ensure patient access to innovative therapies and...
1 week ago
$80K - $95K *
Transform the accounting function by overseeing monthly closes, ensuring compliance, and managing tax processes. Collaborate with finance leadership to drive accurate reporting and support strategic p...
1 week ago
$78K - $206K *
Unlock potential by leading clinical performance improvement projects for Medicare Provider Collaboration groups. Collaborate with teams to enhance population health outcomes, focusing on Stars qualit...
2 weeks ago
$110K - $130K *
Lead the creative vision and execution of impactful design assets, enhancing brand identity and streamlining production processes using AI tools. Collaborate across teams to deliver high-quality marke...
3 weeks ago
Clinical Project Manager - Oncology (Client Dedicated/Remote)
$120K - $135K *
Empower clinical research excellence by managing projects that ensure compliance with regulatory requirements and drive successful study delivery from initiation to closeout. Collaborate with interdis...
Reposted 3 weeks ago
Paralegal & Litigation Specialist
$84K - $99K *
Support impactful litigation and advocacy projects aimed at defending democracy. Collaborate with diverse teams to manage case files, conduct research, and draft legal documents while contributing to...
4 weeks ago
Executive Director, Clinical Supply Consulting & Intelligence
$250K - $350K *
Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...
2 weeks ago
Payment Integrity Program Manager
$73K - $120K *
Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...
3 weeks ago
$146K - $225K *
Manage compliance for the Affirm Card program, ensuring regulatory adherence across marketing, onboarding, and servicing. Collaborate with cross-functional teams to navigate complex compliance challen...
4 weeks ago
Managed Care Contracting and Performance Advisor
$113K - $188K *
Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...
3 days ago
Inside Sales/Provider Representative: CompHealth Medical Staffing
$60K - $250K *
Drive impactful connections in healthcare by matching providers with facilities. Leverage your sales expertise to build relationships, negotiate contracts, and contribute to a rewarding mission that e...
2 weeks ago
Associate Medical Director, Global Safety Physician
$184K - $253K *
Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...
Yesterday
$130K - $160K *
Drive growth as an integral part of our Commercial Sales Team, managing key health system relationships and closing complex deals, while collaborating across departments and shaping the product roadma...
1 month ago
Senior Application Security Engineer
$125K - $150K *
Unlock potential by enhancing application security across web apps and APIs. Collaborate with engineering teams to assess risks, conduct reviews, and drive secure software practices throughout the dev...
3 weeks ago
Business Development Manager - Technical Sales
$100K - $130K *
Join a team that's focused on driving sales in the oil, gas, and energy sectors. You'll cultivate key customer relationships, execute strategic sales plans, and ensure brand excellence across territor...
Reposted 3 weeks ago
$100K - $182K *
Join a team that's dedicated to transforming business needs into innovative software solutions. Collaborate with clients and developers to ensure high satisfaction and successful adoption while advanc...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.