Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$68K - $113K *

Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Champion healthcare project delivery by managing design and construction lifecycles, ensuring compliance with quality, safety, and budget standards while fostering collaboration among stakeholders to...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$69K - $125K *

Transform regulatory insights into actionable strategies by analyzing national and state legislative activities. Collaborate with legal and business teams to ensure compliance and support effective de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$205K - $380K *

Accelerate progress at enterprise sales by driving strategic growth initiatives, building relationships with healthcare leaders, and leading complex sales pursuits to enhance market presence and custo...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$95K - $100K *

Join a dynamic team as a Senior Strategist, where you'll lead data-driven strategies, mentor talent, and drive innovative solutions in healthcare advertising. Collaborate with creative teams to enhanc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $150K *

Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by driving commercial growth strategies for a product family. Collaborate across teams to translate market insights into actionable plans that enhance revenue, profitability, and cust...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$208K - $220K *

Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $230K *

Drive your career with a dynamic role focused on enterprise B2B sales, where you'll cultivate relationships, leverage data insights, and collaborate cross-functionally to close high-value deals in a f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $135K *

Join a team that's redefining digital agreement workflows and secure transactions. As a Mid-Level DocuSign/CLM Developer, you'll collaborate with stakeholders to enhance platform capabilities and deli...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$134K - $249K *

Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $151K *

Elevate your career by representing the organization in claims-related legal matters. Provide expert legal counsel, manage litigation costs, and develop effective strategies to ensure compliance and e...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$113K - $188K *

Elevate your career by leading the strategic development of sustainability programs across international markets, focusing on carbon project design, risk management, and technical innovation to drive...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Develop intuitive, user-centered designs for digital products, collaborating with cross-functional teams to enhance customer experiences. Own the design process from concept to implementation, leverag...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$86K - $138K *

Grow your career by leveraging expertise in cloud platforms to design and implement robust enterprise solutions. Engage in strategic problem-solving and collaborate with teams to ensure operational ex...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $222K *

Innovate your career with a Senior Epic Analyst role focused on designing and optimizing Epic solutions for population health and care coordination, while mentoring junior analysts and collaborating w...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Champion the clinician experience by designing and optimizing tools that enhance daily workflows, ensuring seamless integration of clinical data and improving patient care delivery in home settings...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $175K *

Join a team that's dedicated to managing complex professional liability claims, focusing on legal malpractice. Leverage your expertise to evaluate coverage, negotiate outcomes, and ensure timely reser...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$166K - $244K *

Join a dynamic team to lead the Employer PMO, driving strategic program delivery and cross-functional alignment while enhancing operational efficiency and leveraging modern tools for impactful outcome...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$102K - $170K *

Elevate your career by driving operational improvements in healthcare. Collaborate with clients to enhance performance through data analysis and strategic workflow redesign, ensuring impactful outcome...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$130K - $165K *

Join us to drive the launch of a pioneering biotech product, enhancing healthcare provider engagement and patient outcomes across your territory while achieving sales targets in a dynamic, fast-paced...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $150K *

Unlock potential by serving as a strategic partner to the President, managing priorities, communications, and operations in a fast-paced environment. Your role is crucial in ensuring efficiency and cl...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$173K - $310K *

Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.