Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$83K - $107K *

Elevate digital strategies by integrating user experience with data-driven insights. Collaborate to enhance our online presence, optimize content, and ensure consistency across digital platforms to cr...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$128K - $145K *

Support the full life cycle of vendor contracts, from negotiation to execution. Collaborate with stakeholders to manage legal risks and ensure compliance in a fast-paced environment, focusing on healt...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion statistical programming excellence in oncology clinical trials. Lead programming activities, collaborate with cross-functional teams, and ensure high-quality deliverables from study start-up...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $275K *

Join a team that's driving strategic technology alliances to transform integrations into robust commercial partnerships, focusing on co-selling, joint marketing, and stakeholder alignment while leadin...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Shape the future of discovery operations by leveraging your legal expertise and leadership skills to enhance service delivery and team performance, ensuring top-quality results and efficient workflows...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $100K *

Drive the success of auto lending customer service by fostering relationships, achieving sales targets, and enhancing client satisfaction in your designated area. Leverage your experience to promote p...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$149K - $299K *

Champion exceptional service delivery by leading Help Desk operations, ensuring high-quality support for members and stakeholders. Drive continuous improvement, operational excellence, and effective i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $258K *

Join a dynamic team driving Master Data Management strategies to enhance data governance and operational efficiency across global orthopedic initiatives. Lead cross-functional collaboration to ensure...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$173K - $290K *

Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Elevate your career by managing coding operations, ensuring accuracy and compliance across healthcare settings. Lead educational initiatives for staff, optimize workflows, and drive improvements in co...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$104K - $130K *

Join a team that's driving project success in mission-critical environments. As a Project Manager, you'll oversee design and construction phases, manage stakeholder relations, and ensure project profi...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$250K - $325K *

Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $140K *

Join a team that's driving project success by leading technical initiatives, resolving complex challenges, and aligning outcomes with client objectives. Your expertise will enhance profitability and o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $205K *

Shape the future of AI by designing intuitive tools that empower users to create and manage automated workflows, bridging the gap between technology and user experience in contact centers...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Shape the future of clinical trials by driving business development initiatives, identifying opportunities with sponsors and CROs, and promoting CTSdatabase's services to enhance growth and profitabil...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$68K - $113K *

Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Champion healthcare project delivery by managing design and construction lifecycles, ensuring compliance with quality, safety, and budget standards while fostering collaboration among stakeholders to...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$69K - $125K *

Transform regulatory insights into actionable strategies by analyzing national and state legislative activities. Collaborate with legal and business teams to ensure compliance and support effective de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$205K - $380K *

Accelerate progress at enterprise sales by driving strategic growth initiatives, building relationships with healthcare leaders, and leading complex sales pursuits to enhance market presence and custo...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$95K - $100K *

Join a dynamic team as a Senior Strategist, where you'll lead data-driven strategies, mentor talent, and drive innovative solutions in healthcare advertising. Collaborate with creative teams to enhanc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.