Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Solutions Consulting
$230K - $280K *
Lead a high-performing team to enhance Solutions Consulting, drive cross-functional collaboration and ensure the success of strategic accounts through innovative, accountable deal execution and contin...
Reposted 3 weeks ago
Security Engineer, Corporate Security
$152K - $179K *
Develop and implement security solutions to protect corporate infrastructure, user devices, and applications. Collaborate with IT and engineering teams to identify risks and enhance security measures...
3 days ago
$84K - $87K *
Join us as a Data Operations Engineer, where you'll develop and manage data systems for healthcare claims processing. Collaborate with teams to ensure data accuracy and optimize ETL/ELT pipelines whil...
Reposted 3 weeks ago
$74K - $102K *
Explore and enhance HR systems by supporting configuration, maintenance, and improvements. Collaborate with stakeholders to resolve issues and drive system enhancements in a dynamic environment focuse...
3 weeks ago
Enterprise Account Executive (Founding Team)
$250K - $280K *
Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...
Reposted 2 weeks ago
Supervisor Pharmacy | Cancer Care Institute
$85K - $100K *
Unlock potential by managing pharmacy operations, supervising staff, and ensuring compliance. Cultivate leadership crucial for team growth and efficient workflow while delivering exceptional patient c...
Reposted 2 weeks ago
Manager, Reputation and Consumer Insights
$120K - $150K *
Drive reputation management and consumer insights initiatives, enhancing brand trust and informing strategic decisions. Collaborate across teams to analyze data, identify trends, and improve consumer...
2 weeks ago
Senior Manager, Pain Portfolio
$129K - $185K *
Innovate global medical strategies for the Companion Animal Pain portfolio, driving growth and customer value through scientific engagement, KOL collaboration, and effective market implementation acro...
3 weeks ago
$103K - $128K *
Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...
3 weeks ago
Provider Operations Manager - Credentialing
$73K - $115K *
Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...
3 days ago
Business Systems Analyst, Procure-to-Pay
$100K - $148K *
Transform your career by enhancing Procure-to-Pay systems, collaborating with Finance teams, and driving automation initiatives. Leverage your analytical skills to improve processes and ensure complia...
2 weeks ago
$191K - $305K *
Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...
3 weeks ago
$150K - $180K *
Drive revenue growth by leading a high-performing enterprise sales team, executing strategic sales plans, and building relationships with key decision-makers in the cybersecurity sector. Collaborate c...
3 weeks ago
$210K - $250K *
Drive transformative healthcare initiatives by leading a team of practitioners, optimizing clinical protocols, and enhancing patient care through innovative medical solutions in weight management and...
1 week ago
VP, Payer Sales - National Accounts
$160K - $172K *
Elevate your career by driving growth in national health plan accounts. Leverage your expertise to build relationships, negotiate complex deals, and exceed revenue targets while collaborating with cro...
2 weeks ago
$138K - $191K *
Shape the future of legal operations by managing complex investigations and litigation. Provide expert legal counsel, mitigate risk, and partner with stakeholders to communicate complex issues effecti...
Reposted 2 days ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise to enhance health outcomes. Collaborate with interdisciplinary teams in a dynamic environment, ensuring quality and...
6 days ago
$115K - $150K *
Lead the charge in maintaining operational excellence by overseeing maintenance operations, budgeting, and team development, while implementing safety and efficiency initiatives to enhance equipment r...
Reposted 1 month ago
$110K - $130K *
Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...
6 days ago
$162K - $243K *
Lead a dynamic team in managing complex clinical research trials, ensuring project execution aligns with strategic objectives. Drive process improvements and maintain client relationships while overse...
6 days ago
$162K - $243K *
Lead a dynamic team in managing complex clinical research trials, ensuring strategic execution and client satisfaction. Drive project success through effective communication, budget oversight, and qua...
1 week ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | South Dakota | Telehealth
$80K - $100K *
Transform the way we deliver mental health care to older adults through evidence-based teletherapy. Join a supportive team that prioritizes your autonomy and growth while you manage personalized treat...
4 weeks ago
Project Manager - Medical Publications
$80K - $95K *
Join a team that's dedicated to managing diverse publications projects from start to finish. Collaborate with multidisciplinary teams, ensure client satisfaction, and maintain project budgets while dr...
3 weeks ago
Remote Breast Radiologist - RP Eagle
$250K - $300K *
Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...
1 week ago
$198K - $297K *
Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.