Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Head of Business Development, Pharma/Life Sciences
$200K *
Transform the landscape of life sciences partnerships by driving co-developed deals. Leverage your extensive network and expertise to source, pitch, and close high-value agreements that enhance patien...
Today
$120K - $145K *
Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...
Today
$100K - $122K *
Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...
1 week ago
Medicaid Data & Analytics Specialist
$80K - $95K *
Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...
2 weeks ago
Regional Sales Director - Oklahoma City
$180K - $215K *
Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...
1 week ago
$125K - $144K *
Optimize our data platform by owning end-to-end data engineering projects, leveraging AI coding agents, and ensuring data quality. Collaborate with cross-functional teams to deliver reliable, maintain...
2 days ago
$96K - $144K *
Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...
2 weeks ago
Customer Development Specialist - Dallas/Ft. Worth, TX
$68K - $93K *
Join a team that's dedicated to driving sales in the pet health sector. You'll build relationships with veterinary practices, leverage digital tools, and execute strategies to maximize sales performan...
1 week ago
Staff Physician, 24/7 Care (Full-Time / 100% Remote)
$143K *
Join a team that's redefining virtual healthcare by delivering high-quality, patient-centered care. As a key member, you'll provide comprehensive virtual medical services, collaborate with stakeholder...
Yesterday
$95K - $105K *
Collaborate with us to manage federal government contracts, ensuring compliance and effective execution throughout the contracting lifecycle. Support proposal development, contract administration, and...
Yesterday
$110K - $130K *
Champion client success by managing key relationships and driving strategic initiatives. Lead cross-functional teams to deliver high-quality work while ensuring financial performance and growth for as...
Reposted yesterday
Regulatory and Legal Operations Manager
$110K - $130K *
Optimize regulatory compliance and legal operations in healthcare. Collaborate with cross-functional teams to ensure adherence to industry standards while driving efficiency and effectiveness in legal...
Yesterday
$81K - $122K *
Join a dynamic team to support M&A activities through financial analysis, market research, and transaction coordination. Develop expertise in valuation concepts and contribute to deal documentation an...
6 days ago
Director, Claims Process Optimization ( Facets Required)
$113K - $197K *
Drive automation and AI initiatives in claims operations, enhancing efficiency and accuracy. Lead a team to optimize workflows, manage vendor performance, and ensure compliance while delivering measur...
1 week ago
Senior Federal Platform Engineer
$125K - $150K *
Unlock your potential as you empower deployment and automation solutions in high-security environments. Leverage your expertise in DevOps and platform engineering to ensure robust operations across fe...
Reposted 3 weeks ago
Manager Enterprise Authorization Services
$80K - $95K *
Drive the success of insurance prior authorization processes by leading a team of specialists. Ensure timely approvals and minimize payment denials through effective management, communication, and pro...
2 weeks ago
$88K - $105K *
Join a team that's dedicated to delivering exceptional client service and operational excellence. As a Program Manager, you'll oversee program execution, account management, and financial oversight wh...
2 weeks ago
Customer Support Manager, Provider Enablement
$80K - $95K *
Drive customer support excellence by managing a frontline team to ensure timely resolutions, operational efficiency, and a culture of continuous improvement, paving the way for stellar service in heal...
Reposted today
$70K - $180K *
Drive impactful healthcare technology solutions through data-driven strategies, optimize customer engagements with compelling insights, and foster long-term partnerships for strategic growth...
Reposted 3 days ago
Head of Business Risk & Controls
$180K - $200K *
Lead the development of a robust risk and control framework, ensuring effective identification and management of risks in fiduciary and regulated financial services. Collaborate with stakeholders to e...
2 weeks ago
$110K - $130K *
Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...
2 weeks ago
$110K - $130K *
Advance your career by managing and growing a key business segment, developing strategic sales plans, and fostering relationships with distributors and national accounts to drive revenue and market pr...
3 weeks ago
$95K - $115K *
Unlock client potential by driving adoption and optimizing solutions across legal accounts. Serve as a trusted advisor, ensuring clients maximize their investment in Intapp products while fostering lo...
2 weeks ago
$250K - $286K *
Shape the future of sales by leading a dynamic team to drive new business, refine strategies, and enhance customer experiences in a fast-paced SaaS environment, while mentoring leaders and achieving a...
3 weeks ago
Director, Integrated Specialty Practices
$150K - $180K *
Help us drive business development in oncology by leading strategic partnerships and optimizing resources to enhance clinical outcomes and market potential for our innovative diagnostic and therapeuti...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.