Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Dentist Jobs in South Dakota

Sort By: Relevance

$109K - $184K *

Transform marketing operations by leading a dynamic team to enhance campaign execution, drive automation, and optimize workflows. Collaborate across functions to ensure data-driven, scalable marketing...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Media

$120K - $145K *

Join a team that's redefining data engineering by building scalable data systems and interfaces. You'll design data models, develop real-world use cases, and ensure reliable data flows, all while writ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $95K *

Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Unlock potential by leading high-performing teams in construction disputes and advisory. Drive client relationships, innovate solutions, and ensure quality execution while fostering growth and collabo...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$170K - $200K *

Reimagine retail leadership as you drive sales growth and develop talent across multiple regions. Lead a team of Regional Directors to enhance patient relationships and execute strategic initiatives...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$76K - $96K *

Discover a rewarding career as a Registered Nurse, where you'll deliver compassionate, quality care, collaborate with healthcare teams, and impact patients' lives through expert clinical practice and...

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $300K *

Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$223K - $313K *

Shape the future of healthcare by leveraging your clinical expertise to review Medicare drug appeals, ensuring compliance and optimal value-based care through collaboration and analysis of complex cas...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $155K *

Explore a pivotal role in shaping client relationships and driving agency success. Lead complex projects, mentor teams, and leverage your marketing expertise to deliver impactful solutions in a dynami...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $115K *

Grow your career with a dynamic team driving innovative strategies and customer engagement. Leverage your sales expertise to enhance product visibility and exceed business goals in a supportive, colla...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Join our Clinical Science team to enhance data integrity in CNS trials by conducting meticulous reviews of clinical interviews, ensuring protocol compliance, and guiding site interventions as a Clinic...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Join a dynamic team to drive commercial performance and enhance patient access. Engage healthcare providers, support product launches, and collaborate with cross-functional partners to achieve sales g...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$250K - $325K *

Accelerate your career by leading strategic communications and public policy initiatives that shape the future of AI identity and accountability. Drive visibility, influence industry narratives, and b...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Take ownership of corporate governance and entity management, ensuring compliance and efficiency across multiple subsidiaries. Support M&A and financing activities while maintaining a clean corporate...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Shape impactful B2C marketing strategies and campaigns across multiple channels, driving consumer engagement and retention. Collaborate with teams to create compelling content and optimize performance...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Media

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$177K - $338K *

Help us advance women's health through innovative clinical trial strategies, where you will conduct, support, and report on global studies for cutting-edge compounds, ensuring adherence to regulatory...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Empower provider accounts post-launch by driving growth through strategic engagement, tailored training, and effective collaboration with internal teams. Cultivate relationships across diverse healthc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Unlock potential by shaping mobile development solutions and guiding implementation teams to deliver projects following your architectural designs, ensuring quality and effectiveness throughout the de...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Advance care quality by leading nursing services in Assisted Living and Memory Care. Foster a compassionate environment that empowers residents and supports team excellence, ensuring holistic, person...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$135K - $160K *

Lead mobile solution design and architecture, translating business needs into robust software blueprints. Ensure design adherence, guide implementation teams, and uphold project integrity while collab...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$85K - $95K *

Lead the charge in client engagement and lifecycle management, driving retention and organic growth within legal accounts. Build relationships, identify cross-sell opportunities, and ensure high clien...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$87K - $151K *

Unlock potential by providing expert remote clinical applications support for advanced molecular imaging. Leverage your clinical knowledge and customer service skills to enhance productivity and deliv...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $110K *

Take ownership of third-party risk management by assessing vendors, documenting risks, and ensuring compliance. Collaborate with cross-functional teams to enhance security measures and support audits...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.