Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
eTailer Senior Account Manager, iHerb
$130K - $155K *
Accelerate progress at a leading eCommerce firm by driving global business strategy, overseeing P&L, and enhancing marketplace operations. Leverage your expertise in digital marketing and account mana...
Today
Senior Sales Enablement Strategist
$75K - $135K *
Elevate your career by independently leading high-impact sales enablement initiatives. Utilize your expertise in strategic selling and data-driven insights to improve sales performance and nurture cro...
Reposted 4 weeks ago
$110K - $130K *
Lead the full lifecycle of contracts, ensuring compliance and risk mitigation. Collaborate with internal teams and external partners to draft, negotiate, and manage contracts effectively, while mainta...
1 week ago
$210K - $250K *
Empower oncology research by leveraging real-world evidence and clinical expertise. Collaborate with cross-functional teams to develop innovative solutions that enhance cancer treatment and support bi...
1 week ago
$130K - $145K *
Champion data privacy across jurisdictions by providing expert advice, managing compliance, and supporting initiatives within a global team. Collaborate with colleagues to ensure lawful handling of pe...
Today
Epic Application Analyst - ClinDoc/Stork
$80K - $95K *
Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...
1 week ago
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
6 days ago
$74K - $87K *
Transform customer experiences by leading Unanet ERP implementations, ensuring successful configurations and training for Government Contracting clients. Manage multiple projects, driving adoption and...
3 weeks ago
$75K - $95K *
Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...
6 days ago
$250K - $300K *
Champion innovative neurological care by providing expert medical services to patients. Collaborate with a dedicated team to enhance patient outcomes and advance your practice in a supportive environm...
Reposted 2 days ago
Account Specialist, Palos Heights, IL
$160K - $192K *
Accelerate progress at the forefront of healthcare by driving commercial performance, building relationships with providers, and ensuring patient access to innovative therapies across a defined territ...
1 week ago
Data and AI Governance Specialist
$108K - $149K *
Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...
Reposted 6 days ago
Director of Nursing - RN - Long Term Care
$85K - $100K *
Lead the nursing program in a long-term care facility, ensuring high resident care standards and compliance with regulations. Collaborate with staff and administration to enhance the quality and effic...
Reposted 2 weeks ago
Cardiology Invasive Specialist | Cath Lab
$76K - $93K *
Transform patient care by assisting with invasive cardiovascular procedures. Collaborate with physicians, operate advanced equipment, and ensure accurate documentation while maintaining a sterile envi...
Reposted today
Manager Professional Billing Coding Operations - Remote
$78K - $113K *
Join us to lead the Professional Coding Operations team, ensuring accurate coding practices and compliance. Collaborate with stakeholders, mentor staff, and drive improvements in coding efficiency and...
1 week ago
Senior Director, Enterprise Account Management
$160K - $200K *
Transform the enterprise account management landscape by leading strategy, driving revenue retention, fostering customer growth, and developing high-performing teams to enhance client relationships an...
Reposted 3 weeks ago
Medical Planner - Architecture
$70K - $135K *
Shape the future of healthcare design by collaborating with multidisciplinary teams to develop innovative planning solutions that enhance patient care and operational efficiency in medical facilities...
2 weeks ago
$210K - $260K *
Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...
Reposted 3 weeks ago
$235K - $250K *
Transform financial strategy and compliance in a dynamic fintech environment. Lead financial operations, banking relationships, and compliance initiatives to drive growth and manage risk effectively w...
1 week ago
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
Yesterday
Account Specialist (Macon, GA)
$160K - $192K *
Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...
5 days ago
Senior Consultant - Regulatory
$110K - $130K *
Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...
Reposted 2 days ago
Senior Director Government Programs
$154K - $196K *
Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...
3 weeks ago
Healthcare Tech Manager - Epic Professional Billing
$130K - $150K *
Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...
3 weeks ago
$109K - $184K *
Transform marketing operations by leading a dynamic team to enhance campaign execution, drive automation, and optimize workflows. Collaborate across functions to ensure data-driven, scalable marketing...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.