Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Dentist Jobs in Pennsylvania

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$116K - $229K *

Transform commercial operations by leveraging AI and analytics to drive innovative solutions for Life Sciences clients. Collaborate with high-performing teams to enhance data-driven decision-making an...

6 days ago

  •   Less than 5 years exp.  •   Business Services

$116K - $229K *

Innovate data-driven solutions for Life Sciences, leveraging AI and analytics to transform commercial operations. Collaborate with teams to deliver insights and optimize strategies for pharma clients...

6 days ago

  •   Less than 5 years exp.  •   Business Services

$140K - $160K *

Transform AI analytics by executing measurement frameworks and optimizing performance across voice and chat channels. Collaborate with cross-functional teams to deliver actionable insights and enhance...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$114K - $136K *

Contribute to residents' well-being by assessing needs, developing care plans, and coordinating services. Collaborate with interdisciplinary teams to ensure emotional and psychosocial support, enhanci...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by collaborating with cross-functional teams to enhance business operations, streamline processes, and drive value through effective analysis and documentation. Your expertise will...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$71K - $100K *

Drive strategic initiatives by analyzing market trends and performance metrics. Collaborate with cross-functional teams to develop business cases and forecasts, ensuring data integrity and delivering...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Execute the successful delivery of complex projects by leading all phases of the project lifecycle, ensuring alignment with business objectives and quality standards, while managing resources, risks...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform project delivery by leading mid to large-scale initiatives, ensuring timely and quality execution while managing resources and stakeholder communication. Hone strategic planning and effectiv...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Innovate your career by building agile marketing systems that leverage AI and data. Own the demand generation engine, connecting audience insights and multi-channel campaigns to drive measurable growt...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$99K - $104K *

Join a dynamic cardiology practice as a Vascular Ultrasound Technologist, performing high-quality vascular exams, collaborating with healthcare professionals, and ensuring exceptional patient care in...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $170K *

Support our Legal team by managing the contract lifecycle, drafting agreements, and ensuring compliance. Collaborate with the Supply team to enhance contracting processes and infrastructure in a fast...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $156K *

Empower young children and families by providing tailored speech therapy in their natural environment. Enjoy flexible scheduling and a supportive team while making a meaningful impact on early develop...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Elevate patient care by providing comprehensive medication management in a collaborative environment. You'll work with healthcare teams across diverse specialties, enhancing your clinical expertise wh...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Empower teams by managing multiple projects across various brands, ensuring timely and budget-friendly deliverables. Collaborate with cross-functional leads to enhance processes and support direct rep...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$300K *

Manage the complete sales cycle by identifying leads, building relationships, and closing deals efficiently while collaborating with cross-functional teams to enhance customer success and drive the ad...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Inspire patient recruitment strategies by leading a dynamic team, collaborating with senior management, and leveraging innovative tools to enhance enrollment across clinical trials while ensuring dive...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Champion exceptional patient care by leading a dynamic team in a collaborative environment, enhancing education and research while delivering high-quality healthcare services to the community...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a dynamic Legal team to provide actionable regulatory advice across pharmacy laws, impacting healthcare and e-commerce. Collaborate with diverse business units to navigate complex legal landscape...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Engage with a collaborative team to manage complex insurance coverage cases, offering significant responsibilities and opportunities for professional growth in a hybrid work environment...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $220K *

Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Design and implement robust cybersecurity architectures to safeguard healthcare operations. Collaborate with cross-functional teams to assess risks, develop solutions, and enhance security standards...

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$130K - $140K *

Drive your career as a District Sales Manager leading a team in the healthcare sector. Deliver sales strategies, exceed objectives, and foster strong cross-functional collaboration while ensuring exem...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$164K - $282K *

Lead the charge in shaping global regulatory strategies for innovative orthopaedic products. Drive excellence in product launches and portfolio management while mentoring a talented team to ensure com...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$136K - $204K *

Drive the development of AI and technology certification programs for law schools, enhancing legal education engagement and establishing Clio as a trusted partner in the academic community through inn...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.