Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Dentist Jobs in Pennsylvania

Sort By: Relevance

$105K - $250K *

Empower clients by developing tailored financial strategies that meet their unique goals. Collaborate with partners to enhance wealth management practices, fostering strong client relationships in a d...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$93K - $159K *

Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $95K *

Drive exceptional client experiences and revenue growth by leading a high-performing sales team, converting qualified leads, and fostering a culture of continuous improvement in a consultative sales e...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$425K *

Join our team to provide exceptional anesthesia care across diverse surgical settings, ensuring patient safety and comfort while collaborating with a dedicated group of professionals in a dynamic heal...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock the potential of CAR T cell therapies by leading genetic regulation projects, optimizing gene modulation strategies, and collaborating with diverse teams to enhance therapy efficacy and safety...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$268K - $466K *

Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$262K - $404K *

Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$137K - $235K *

Join a team that's transforming clinical and omics data into AI-ready assets. Lead the end-to-end data product lifecycle, ensuring quality and interoperability while mentoring junior engineers and col...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$340K - $400K *

Lead the charge in delivering exceptional orthopedic care as a fellowship-trained surgeon, collaborating with a dedicated team to enhance community health through innovative hip and knee arthroplasty...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Join a dynamic team to support product management for government insurance, ensuring compliance and driving strategic initiatives. Leverage your expertise to lead analysis, define requirements, and en...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $90K *

Lead data-driven insights to enhance business performance, collaborating across teams to support strategic initiatives. Utilize technical skills in SQL, Python, and data visualization to drive impactf...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $95K *

Take ownership of patient health as a Dietitian in acute care. Deliver individualized nutrition assessments, education, and evidence-based therapies while collaborating with a dedicated team to enhanc...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$90K - $110K *

Shape the future of government insurance products by guiding compliance, leading market analyses, and enhancing product strategies. Collaborate on product management projects to drive alignment and fo...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $105K *

Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $308K *

Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $115K *

Join a team that's focused on diversifying paid media channels and optimizing conversion strategies. You'll lead initiatives across affiliate, programmatic, and social platforms to enhance member acqu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform client engagements by conducting regulatory research and analysis in Medicare Advantage, Medicaid managed care, and ACA programs. Develop findings and deliverables while ensuring compliance...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$180K - $220K *

Unlock potential by leading clinical care and research for complex vascular anomalies. Engage in teaching, patient care, and interdisciplinary collaboration. Play a pivotal role in advancing pediatric...

4 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$145K - $195K *

Unlock patient engagement strategies by integrating insights into drug development. Collaborate with diverse teams to generate evidence, engage with professional societies, and lead initiatives that p...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to optimizing privacy management processes and compliance technology. This role supports platform administration, user engagement, and operational improvements, ensuring e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $95K *

Join a team that's dedicated to improving patient outcomes through expert nutrition therapy. Collaborate within a dynamic environment to provide personalized care and education, driving health initiat...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$132K - $185K *

Lead security consulting engagements, delivering Cisco solutions and training. Collaborate with teams to design, implement, and optimize security architectures, ensuring customer satisfaction and valu...

4 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$200K *

Transform the landscape of life sciences partnerships by driving co-developed deals. Leverage your extensive network and expertise to source, pitch, and close high-value agreements that enhance patien...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.