Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Dentist Jobs in Pennsylvania

Sort By: Relevance

$110K - $130K *

Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $95K *

Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$76K - $102K *

Elevate your career by joining a dynamic imaging team, performing advanced CT procedures while ensuring high-quality patient care through your clinical expertise and independent judgment...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$170K - $200K *

Reimagine retail leadership as you drive sales growth and develop talent across multiple regions. Lead a team of Regional Directors to enhance patient relationships and execute strategic initiatives...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $150K *

Join a collaborative team to enhance application security across the SDLC and CI/CD pipeline, ensuring compliance with healthcare regulations while managing vulnerabilities and incident responses in a...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$66K - $105K *

Elevate workplace safety and sustainability by partnering with engineering teams to identify risks, implement solutions, and drive continuous improvement within a manufacturing environment...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $120K *

Unlock your potential as a licensed counselor, providing impactful telehealth services to clients navigating emotional and behavioral challenges. Engage in meaningful client interactions while maintai...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$223K - $313K *

Shape the future of healthcare by leveraging your clinical expertise to review Medicare drug appeals, ensuring compliance and optimal value-based care through collaboration and analysis of complex cas...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by leading claims operations, resolving complex issues, and enhancing workflows across medical and pharmacy claims. Collaborate with diverse teams to ensure accurate payments and impr...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Drive excellence in patient care by diagnosing and managing infectious diseases. Collaborate with a multidisciplinary team to provide evidence-based treatment and enhance educational initiatives withi...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Elevate data accuracy by analyzing user queries and improving AI responses. Collaborate with Product Management, Data Science, and Engineering to ensure Prism delivers trustworthy insights, enhancing...

Philadelphia, PARemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform data analysis in life sciences by ensuring accurate AI responses. Collaborate with Product Management, Data Science, and Engineering to enhance our conversational analytics platform, driving...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $115K *

Grow your career with a dynamic team driving innovative strategies and customer engagement. Leverage your sales expertise to enhance product visibility and exceed business goals in a supportive, colla...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $155K *

Explore a pivotal role in shaping client relationships and driving agency success. Lead complex projects, mentor teams, and leverage your marketing expertise to deliver impactful solutions in a dynami...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Elevate patient care by managing in-basket communications and providing proactive services as a hybrid Nurse Practitioner or Physician Assistant, balancing in-office presence with virtual support for...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join our Clinical Science team to enhance data integrity in CNS trials by conducting meticulous reviews of clinical interviews, ensuring protocol compliance, and guiding site interventions as a Clinic...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Lead the charge in delivering high-quality, patient-centered care while providing strategic and operational leadership as the Medical Director of Internal Medicine. Collaborate with faculty and health...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $192K *

Join a dynamic team to drive commercial performance and enhance patient access. Engage healthcare providers, support product launches, and collaborate with cross-functional partners to achieve sales g...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Take ownership of corporate governance and entity management, ensuring compliance and efficiency across multiple subsidiaries. Support M&A and financing activities while maintaining a clean corporate...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $325K *

Accelerate your career by leading strategic communications and public policy initiatives that shape the future of AI identity and accountability. Drive visibility, influence industry narratives, and b...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Drive clinical excellence by leading virtual care operations, enhancing patient safety, and fostering staff development. Collaborate with teams to optimize workflows and ensure high-quality patient ca...

Pittsburgh, PARemote

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Champion clinical excellence by leading virtual care operations, enhancing patient safety, and fostering staff development. Drive workflow improvements and support a collaborative environment to optim...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Champion quality patient care by leveraging your Advanced Practitioner degree to enhance communication and collaboration within the healthcare team, driving optimal patient outcomes in an inpatient ga...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Shape impactful B2C marketing strategies and campaigns across multiple channels, driving consumer engagement and retention. Collaborate with teams to create compelling content and optimize performance...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Media

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.