Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$214K - $308K *

Empower security excellence by leading high-performing teams, driving strategic initiatives, and collaborating across functions. Own major security programs and represent the organization to executive...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Empower the development of mission-critical applications on the ServiceNow platform, collaborating with stakeholders to deliver scalable solutions while ensuring compliance with federal standards and...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$118K - $142K *

Engage in comprehensive site monitoring and management for clinical trials, ensuring adherence to protocols and regulatory standards while providing high-quality care and support to study participants...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$62K - $127K *

Join a team that's dedicated to delivering exceptional customer service while managing complex general liability claims. Collaborate with legal partners to develop strategies for effective resolution...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Elevate your career by building transformative backend services and distributed systems that empower enterprises to monitor AI effectively. Drive projects from vague concepts to deployed products whil...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$246K - $332K *

Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Join a team that's transforming customer onboarding by leading complex implementations, aligning stakeholders, and delivering scalable solutions that drive success and revenue. Your expertise will bri...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$193K - $262K *

Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate growth at a leading cyber security provider by driving enterprise sales. Utilize your strategic selling skills and build key relationships with C-level execs to implement innovative solutio...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$230K - $270K *

Shape the future of compliance technology by leading the design and implementation of data-driven solutions that meet global regulatory standards, ensuring operational efficiency and effectiveness acr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Innovate with us to drive strategic product marketing initiatives that enhance capital equipment and consumable sales. Lead go-to-market strategies and foster market adoption, ensuring alignment with...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Drive litigation strategy and outcomes in a dynamic P&C environment, leading a team to enhance operational effectiveness and improve policyholder experiences while managing diverse liability and cover...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$141K - $234K *

Lead the charge in healthcare performance improvement by overseeing project delivery, managing client relationships, and mentoring a team of Advisory consultants to ensure successful, high-quality out...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Engage healthcare providers and drive commercial performance in a defined territory. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative therapi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $114K *

Join a team that's dedicated to enhancing patient care as a Speech Language Pathologist. Collaborate with health professionals in a supportive environment, providing essential therapy services to impr...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$190K - $262K *

Join us to ensure high-quality radiation therapy through expert oversight, compliance, and innovative practices. Collaborate with a dedicated team to enhance patient safety and deliver exceptional car...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$123K - $169K *

Elevate healthcare data integration by leading client engagements, optimizing EHR extracts, and providing strategic guidance. Utilize your SQL expertise to ensure data accuracy and foster strong clien...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$88K - $140K *

Drive the development of predictive analytics models to enhance digital assessment operations, collaborating across teams to optimize decision-making and reduce costs while supporting strategic goals...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $149K *

Join a team that's dedicated to providing legal support in mortgage servicing. You'll ensure compliance with regulations, draft essential documents, and collaborate with operational teams to minimize...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$252K - $315K *

Drive innovation in interventional psychiatry by developing evidence-based programs and protocols. Collaborate with clinical teams to enhance patient outcomes and ensure compliance with regulatory sta...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $158K *

Join our team as an SAP EHS Dangerous Goods Specialist, where you'll lead the configuration and support of critical processes, ensuring compliance with global regulations while collaborating across fu...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.