Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$110K - $130K *

Transform product vision into reality by leading the Encoder solution, managing backlogs, and collaborating with stakeholders to maximize value and user satisfaction. Drive strategic decisions and ens...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$69K - $119K *

Transform the landscape of clinical documentation by educating and mentoring teams, ensuring compliance, and enhancing documentation accuracy to optimize patient care and coding outcomes...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$157K - $212K *

Lead the charge in enhancing AI search functionality, empowering legal professionals to seamlessly find documents. Collaborate with engineering teams to optimize search relevance, performance, and use...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$175K *

Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$121K - $155K *

Empower individuals by providing evidence-based mental health support to patients aged 13+. Collaborate with a dedicated clinical team in a fully remote environment, enhancing patient care and profess...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$153K - $203K *

Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $130K *

Lead the charge in enhancing member care as you coach and develop clinical teams, oversee daily operations, and ensure compliance with regulatory standards while driving quality improvements and opera...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $177K *

Transform the sales training landscape by designing and executing innovative educational programs for Trauma & Extremities, enhancing team competency and driving strategic growth in alignment with glo...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $110K *

Drive your career with a Senior Accountant role focused on AI and automation. Redesign accounting processes, manage monthly closes, and implement scalable finance workflows to enhance efficiency and s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$90K - $110K *

Transform patient care by assisting Gastroenterology faculty in delivering comprehensive diagnostic and therapeutic services, ensuring optimal outcomes for adult patients in outpatient and infusion se...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $135K *

Lead the innovation and optimization of a digital customer experience platform, collaborating with cross-functional teams to drive growth and operational excellence through strategic product managemen...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Drive security excellence by managing identity access, external testing, and compliance processes. Collaborate with teams to enhance AWS security and develop scalable policies, ensuring robust protect...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$136K - $181K *

Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $259K *

Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Drive cloud security innovation by establishing best practices, building security tools, and collaborating with development teams to embed security in design. Ensure compliance and protection across c...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$167K - $229K *

Lead the charge in transforming clinical decision-making strategies within health insurance, ensuring compliance and quality in medical reviews while advancing innovation in medical management and cro...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $236K *

Lead the charge in developing strategic partnerships for Oura's innovative in-ring payment solutions. Drive commercial agreements, build cross-functional alignment, and shape a roadmap for expanding p...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Drive managed care contracting activities, supporting payer negotiations and relationships. Collaborate with leadership to execute center-level priorities and enhance client satisfaction through effec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$168K - $231K *

Drive transformation by partnering with cross-functional teams to design and implement effective product operations, ensuring alignment with strategic goals and enhancing organizational effectiveness...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$86K - $113K *

Engage with clients as a trusted partner, driving satisfaction and growth through effective management of healthcare operations and strategic initiatives. Collaborate across teams to enhance service d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Lead the charge in delivering high-quality, relationship-based care to seniors. Collaborate with interdisciplinary teams to enhance patient outcomes and ensure comprehensive care in skilled nursing an...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$136K - $187K *

Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.