Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$100K - $120K *

Deliver exceptional customer value by driving onboarding, adoption, and long-term success for a portfolio of clients. Leverage commercial insight and strong relationships to maximize platform utilizat...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$129K - $177K *

Lead the charge in architecting scalable and reliable systems critical for real-time decision making. Own platform performance, quality, and operational excellence while mentoring a dynamic team and c...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Elevate healthcare interoperability by designing and supporting MEDITECH interfaces. Collaborate with teams to enhance data exchange, improve patient care, and ensure seamless integration across syste...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive customer success by fostering executive relationships and ensuring retention and growth across a defined portfolio. Leverage strategic insights to translate customer outcomes into measurable bus...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Deliver exceptional consulting services by managing client implementations, diagnosing technical issues, and providing tailored solutions. Collaborate with cross-functional teams to ensure seamless in...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$86K - $118K *

Join a team that's dedicated to enhancing consumer experiences through innovative solutions. Leverage your technical expertise in a collaborative environment focused on continuous improvement and impa...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$164K - $205K *

Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join our team to provide legal and regulatory guidance in mortgage lending and insurance. You'll research, advise, and manage compliance matters while collaborating with stakeholders to mitigate risks...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$130K - $150K *

Join a team that's shaping high-impact strategies and narratives for enterprise growth. Collaborate with senior leaders to craft compelling pitches and support organic initiatives, driving success acr...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Drive impactful marketing strategies in the Healthcare sector, enhancing positioning and messaging. Collaborate cross-functionally to accelerate growth and establish thought leadership, ensuring relev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Elevate your career by leading strategic IT solutions and driving software asset management excellence. Collaborate with stakeholders, mentor peers, and influence outcomes through innovative analysis...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Analyze clinical documentation and risk adjustment for healthcare providers, ensuring accurate representation of patient acuity. Collaborate with physicians to identify documentation opportunities and...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$89K - $151K *

Deliver exceptional automation solutions that enhance operational efficiency and accuracy across the healthcare revenue cycle. Lead strategic initiatives to streamline processes, optimize performance...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$191K - $238K *

Shape the future of oncology by leading medical strategy for prostate cancer projects. Collaborate with cross-functional teams to drive scientific communication and strategic initiatives, ensuring ali...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Advance patient care in a collaborative healthcare environment. As a Nurse Practitioner, you'll assess, diagnose, and treat patients while coordinating care across multiple programs, ensuring high-qua...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $150K *

Elevate payment integrity operations by leading a team focused on dispute resolution, compliance, and provider education. Drive data analysis and operational excellence to enhance collaborative relati...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$119K - $186K *

Advance your career by providing strategic legal counsel on data governance, privacy, and cybersecurity within a dynamic healthcare environment. Collaborate with cross-functional teams to drive compli...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Elevate your sales career by building lasting client relationships and driving revenue growth. This role focuses on strategic account management, fostering connections, and leveraging a dedicated mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$54K - $155K *

Lead the charge in telephonic case management, collaborating with patients and care teams to support quality healthcare delivery. Use clinical expertise to assess needs, implement strategies, and ensu...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Lead data architecture initiatives by optimizing serverless data pipelines and enhancing analytics capabilities through AWS services like SageMaker and Glue. Collaborate on data lakes and AI integrati...

RemoteRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform the interaction of mobile robots with their environments by developing cutting-edge learning-based manipulation systems that enhance reliability and safety in dynamic settings, impacting rea...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $259K *

Lead the charge in optimizing global drug safety operations, ensuring compliance and excellence in pharmacovigilance. Drive strategic initiatives, manage vendor relationships, and enhance processes to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.