Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$221K - $335K *

Elevate clinical research by leading innovative studies, ensuring data integrity and patient safety. Collaborate cross-functionally to drive strategic initiatives and enhance clinical development whil...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Champion the management and execution of complex e-discovery projects, collaborating with legal teams to ensure successful outcomes. Oversee multiple projects while mentoring a team, maintaining quali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$126K - $189K *

Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Unlock potential by driving new enterprise sales in cybersecurity. Own the full sales cycle, from prospecting to closing, while expanding existing accounts. Collaborate with teams to deliver tailored...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $150K *

Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovativ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform claims management by leading strategic initiatives, overseeing operations, and driving continuous improvement across a diverse portfolio, ensuring optimal outcomes and compliance while colla...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$79K - $94K *

Optimize training and workflow processes by leading program development, mentoring trainers, and collaborating with stakeholders to enhance provider experiences and operational efficiency across Care...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Champion a high-growth sales strategy by developing a results-driven team to achieve revenue targets, expand market presence, and foster strategic client relationships while ensuring continuous improv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$195K - $217K *

Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform data into actionable insights by building robust data pipelines, dashboards, and monitoring frameworks. Leverage expertise in Skyline DataMiner to enhance network performance analytics and e...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Staffing

$130K - $155K *

Accelerate progress at a leading eCommerce firm by driving global business strategy, overseeing P&L, and enhancing marketplace operations. Leverage your expertise in digital marketing and account mana...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$75K - $135K *

Elevate your career by independently leading high-impact sales enablement initiatives. Utilize your expertise in strategic selling and data-driven insights to improve sales performance and nurture cro...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the full lifecycle of contracts, ensuring compliance and risk mitigation. Collaborate with internal teams and external partners to draft, negotiate, and manage contracts effectively, while mainta...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$210K - $250K *

Empower oncology research by leveraging real-world evidence and clinical expertise. Collaborate with cross-functional teams to develop innovative solutions that enhance cancer treatment and support bi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $145K *

Champion data privacy across jurisdictions by providing expert advice, managing compliance, and supporting initiatives within a global team. Collaborate with colleagues to ensure lawful handling of pe...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$132K - $153K *

Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Join a collaborative team providing advanced emergency care for pets. Play a key role in delivering exceptional veterinary services, ensuring the best outcomes through integrated specialist support an...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Join a collaborative team to provide advanced emergency care for pets, ensuring optimal outcomes through integrated specialist support and ongoing professional development opportunities...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$74K - $87K *

Transform customer experiences by leading Unanet ERP implementations, ensuring successful configurations and training for Government Contracting clients. Manage multiple projects, driving adoption and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $95K *

Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Accelerate progress at the forefront of healthcare by driving commercial performance, building relationships with providers, and ensuring patient access to innovative therapies across a defined territ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $149K *

Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.