Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$70K - $105K *

Innovate your career as a Senior Research Scientist, conducting complex research, mentoring teams, and contributing to impactful publications within a collaborative environment focused on Psychiatry a...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$70K - $105K *

Design and deliver comprehensive training programs for law enforcement personnel, ensuring compliance with departmental and national standards. Manage training documentation and equipment procurement...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Elevate neurorehabilitation research by developing an independent program focused on stroke and brain injury recovery. Collaborate across disciplines to translate discoveries into practice and improve...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Help us drive technical strategy and solutions for enterprise clients, addressing security challenges and delivering impactful demonstrations. Collaborate with cross-functional teams to translate comp...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$123K - $207K *

Grow your career with a dynamic sales role managing strategic brokerage accounts. Drive revenue growth through relationship building, solution selling, and navigating complex sales cycles in a fast-pa...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in delivering Microsoft 365 consulting engagements, focusing on SharePoint Online and modern collaboration tools. Drive client relationships, solution design, and governance while ment...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$150K - $183K *

Join a team that's driving growth by acquiring and managing Mid-Market accounts. You'll identify prospects, manage the sales cycle, and build lasting relationships to exceed revenue targets in a dynam...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$110K - $120K *

Partner with us to lead financial management for Care in Action, overseeing budgeting, reporting, and compliance across multiple entities. Drive strategic financial stewardship while ensuring organiza...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K - $100K *

Champion community engagement by building strategic relationships across sectors, enhancing civic partnerships, and addressing key issues affecting the Jewish community. Drive initiatives that foster...

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Unlock operational excellence by leading maintenance planning for fleet reliability and readiness. Collaborate with cross-functional teams to prioritize repairs, manage recalls, and optimize vehicle l...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform your career by driving growth and client success in a dynamic market. Collaborate with cross-functional teams to enhance operational excellence, expand revenue, and deliver exceptional clien...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$104K - $174K *

Champion the development of sales professionals by designing and delivering impactful training programs. Collaborate with leadership to enhance skills, knowledge, and effectiveness, ensuring a consist...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$156K - $239K *

Innovate advanced ArcGIS deployments, collaborating with clients to optimize architecture and integration. Join a dynamic team dedicated to enhancing community impact through cutting-edge web and mobi...

Today

  •   11 - 15 years exp.  •   Information Technology

$79K - $133K *

Drive the design and development of geospatial solutions for utilities, enhancing operations and services across multiple industries, including electric, gas, and telecommunications, while collaborati...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$97K - $162K *

Elevate your career by building innovative backend services that leverage cutting-edge GIS technologies. Collaborate with a passionate team to create impactful solutions for Defense and Intel clients...

Today

  •   Less than 5 years exp.  •   Information Technology

$107K - $182K *

Lead the charge in building strategic partnerships with system integrators to drive revenue growth and ArcGIS adoption. Collaborate across teams to enhance partner engagement and execute go-to-market...

Today

  •   5 - 7 years exp.  •   Information Technology

$184K - $356K *

Transform the future of AI by serving as a technical advisor, driving GPU infrastructure projects and guiding partners through design and deployment. Collaborate cross-functionally for innovative solu...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $206K *

Pioneer impactful clinical strategies to enhance Medicare medication use. Lead a dynamic team, ensuring performance goals are met while navigating complex healthcare challenges. Drive innovation and c...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$224K - $356K *

Transform AI inference by leading the development of advanced GPU-accelerated software, driving feature innovation, and enhancing customer adoption in a collaborative open-source environment...

RemoteRemote

Reposted today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $234K *

Lead the charge in optimizing SAP Sales and Distribution processes. Collaborate with cross-functional teams to enhance order-to-cash operations while mentoring junior consultants and driving continuou...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$94K - $178K *

Elevate application migration success by leading Agile teams through assessments, planning, and execution. Drive collaboration and ensure seamless delivery while managing complex projects aligned with...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$135K - $150K *

Drive new business acquisition and revenue growth by proactively selling innovative FinTech solutions to enterprise clients, while managing complex sales cycles and building strategic relationships wi...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Transform enterprise data management by leading MDM strategies and architectures. Collaborate with stakeholders to ensure data quality and governance while integrating solutions across platforms like...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$120K - $145K *

Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Unlock AI-driven software engineering across the SDLC, transforming SCM applications through innovative practices. Drive measurable outcomes in productivity, code quality, and deployment efficiency wh...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.