Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Neurology - Thought Leader Liaison (SOUTHEAST)
$245K - $265K *
Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...
2 weeks ago
Payer Strategy & Analytics Senior
$103K - $192K *
Shape the future of healthcare reimbursement by leading analytics for payor contracting and out-of-network strategies. Collaborate with cross-functional teams to optimize financial outcomes and drive...
2 days ago
Area Director, Electrophysiology & Structural Heart-West
$176K - $243K *
Unlock potential by driving the adoption of advanced electrophysiology solutions through strategic partnerships, enhancing customer engagement, and fostering relationships with key stakeholders to ens...
Yesterday
Principal System Architect - MedDevice
$198K - $258K *
Lead the charge in defining and governing architectural strategies for a secure and scalable software ecosystem across device and digital platforms, influencing cross-functional teams and senior stake...
Reposted 5 days ago
Medical Director, Utilization Management
$180K - $220K *
Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...
Today
Senior Manager, Data Science & Advanced Analytics
$170K - $190K *
Transform data into actionable insights by leading a team of data scientists and analysts. Drive advanced analytics initiatives, foster collaboration with stakeholders, and ensure high-quality deliver...
6 days ago
$95K - $115K *
Empower your career by providing analytic support for performance improvement and labor productivity initiatives. Collaborate with leaders to develop standards, enhance data integrity, and optimize be...
1 week ago
Nurse Practitioner or Physician Assistant | Hematology and Transplant | Inpatient
$90K - $110K *
Transform patient care by guiding Oncology patients through complex treatment plans, ensuring a smooth experience and providing essential medical services. Collaborate with healthcare teams to deliver...
Yesterday
Director, Drug Safety Physician
$280K - $311K *
Optimize safety evaluations within our Drug Safety team to drive innovative strategies for monitoring and managing clinical risks, ensuring compliance and maintaining high-quality standards in pharmac...
4 weeks ago
$126K - $189K *
Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...
4 weeks ago
$84K - $126K *
Empower decision-making by transforming data into intuitive models. Collaborate with stakeholders to ensure metrics are clear and trusted, while optimizing data for analytics and reporting across the...
Yesterday
$100K - $130K *
Grow your career with a dynamic role that involves conducting in-depth research across various topics, delivering actionable insights, and collaborating with a high-performing team to tackle complex q...
3 weeks ago
Physician | Radiation Oncologist
$250K - $300K *
Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...
3 weeks ago
Senior Director, Head of Research & Early Development
$228K - $342K *
Empower your career by leading strategic project management initiatives across early drug development. Drive process optimization, cultivate high-performing teams, and collaborate with executives to a...
Today
$80K - $95K *
Join our Clinical Science team to enhance data integrity in CNS trials by conducting meticulous reviews of clinical interviews, ensuring protocol compliance, and guiding site interventions as a Clinic...
Reposted 4 weeks ago
Cardiology Invasive Specialist | Cath Lab
$76K - $93K *
Transform patient care by assisting with invasive cardiovascular procedures. Collaborate with physicians, operate advanced equipment, and ensure accurate documentation while maintaining a sterile envi...
Reposted today
$150K - $180K *
Contribute to the design and execution of clinical studies, ensuring data integrity and quality. Collaborate cross-functionally to drive study activities and support regulatory efforts, while enhancin...
2 weeks ago
Procurement Manager, Process & Policy
$93K - $159K *
Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...
1 week ago
Associate Director, Clinical Operations
$130K - $160K *
Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...
2 weeks ago
National Account Director - Market Access & Payer Strategy
$175K - $185K *
Champion strategic payer engagement to enhance access and reimbursement across a national portfolio. Drive medical policy influence and build relationships with key stakeholders to expand coverage and...
3 weeks ago
Sr. Reimbursement Analyst (Ops) - Remote
$101K - $152K *
Unlock your potential by supporting reimbursement operations and strategic initiatives that enhance patient access across diverse therapies. Collaborate with cross-functional teams to drive process im...
Reposted 5 days ago
$160K - $190K *
Pioneer innovative AI solutions to transform biomedical discovery, collaborating with top scientists and engineers to bridge virtual and real-world data, enhancing drug discovery and clinical care pro...
Today
Manager, Case Management (LCSW/LMFT)
$90K - $115K *
Champion clinical excellence by leading and mentoring a dynamic ECM team, ensuring comprehensive patient care and adherence to individualized plans, while collaborating effectively with multidisciplin...
Reposted 4 weeks ago
Clinical Applications Specialist, Invasive Cardiology
$92K - $138K *
Help us enhance clinical education by delivering expert training and support to healthcare professionals. Drive product adoption and optimize user competencies while fostering strong relationships wit...
2 weeks ago
Associate Director, Analytics Governance & Operations
$152K - $283K *
Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.