Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Certified Registered Nurse Anesthetist | Spearfish Hospital
$160K - $190K *
Join a team that's dedicated to providing expert anesthesia care. As a CRNA, you will collaborate with surgeons, utilizing your skills to enhance patient outcomes in a supportive environment that valu...
Reposted today
$250K - $300K *
Champion innovative neurological care by providing expert medical services to patients. Collaborate with a dedicated team to enhance patient outcomes and advance your practice in a supportive environm...
Reposted 2 days ago
$210K - $260K *
Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...
Reposted 3 weeks ago
Associate Medical Director (RadScience)
$110K - $130K *
Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...
1 week ago
$80K - $96K *
Join a team that's dedicated to advancing anesthesiology practices, promoting CRNA autonomy in a supportive environment. Engage in diverse cases at a Level II trauma center while enjoying a flexible d...
3 weeks ago
$125K - $150K *
Lead a dynamic anesthesiology team in a Level II trauma center, ensuring high-quality patient care and promoting CRNA autonomy. Collaborate effectively with anesthesiologists while managing diverse ca...
3 weeks ago
Associate Medical Director- Rare Neuro
$175K - $200K *
Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...
Reposted 2 days ago
$160K - $200K *
Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...
Today
$198K - $297K *
Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...
Yesterday
$115K - $135K *
Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...
3 weeks ago
$210K - $250K *
Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...
1 week ago
Manager, Credentialing & Medical Staff Services
$110K - $125K *
Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...
2 weeks ago
$125K - $150K *
Pioneer in radiology innovation by enhancing clinical value and technology. Join a forward-thinking team that prioritizes high-quality patient care while driving improvements in service and operationa...
Reposted 2 weeks ago
Advanced Practice Provider - Pain Management
$90K - $110K *
Elevate patient care by managing complex cases in collaboration with healthcare teams. Utilize your expertise to assess, diagnose, and implement treatment plans, ensuring optimal outcomes in an outpat...
3 weeks ago
$80K - $95K *
Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...
2 weeks ago
$240K - $300K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
6 days ago
Physician Relations Team Manager
$106K - $167K *
Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...
Yesterday
Nurse Practitioner or Physician Assistant | Neurology | Inpatient
$90K - $110K *
Take ownership of patient care by assessing, diagnosing, and treating individuals. Collaborate with physicians to develop care plans, educate patients, and ensure quality health services in a supporti...
1 week ago
Principal Scientist, In Vivo Pharmacology, Neurology
$173K - $205K *
Shape the future of neurology by leading in vivo pharmacology studies, collaborating with cross-functional teams, and driving data-driven decisions for IND submissions in a dynamic biotech environment...
4 weeks ago
Physician - Diagnostic Tele-Radiologist
$210K - $250K *
Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...
1 week ago
$100K - $140K *
Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...
3 weeks ago
$100K - $120K *
Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...
Today
Director, Neurology - Thought Leader Liaison (WEST)
$220K - $250K *
Shape the future of neurology by building partnerships with Medical Experts, generating insights, and collaborating across teams to enhance patient care and drive innovation in a dynamic healthcare la...
Reposted 1 week ago
$260K - $270K *
Unlock your potential as a Psychiatrist, providing advanced outpatient care via virtual platforms. Collaborate with multidisciplinary teams to deliver comprehensive treatment for diverse psychiatric c...
6 days ago
Associate Vice President - Early Development Clinical Research Physician - Neuroscience
$268K - $466K *
Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...
1 month ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.