Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Anesthesiologist Jobs in South Dakota

Sort By: Relevance

$160K - $190K *

Join a team that's dedicated to providing expert anesthesia care. As a CRNA, you will collaborate with surgeons, utilizing your skills to enhance patient outcomes in a supportive environment that valu...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Champion innovative neurological care by providing expert medical services to patients. Collaborate with a dedicated team to enhance patient outcomes and advance your practice in a supportive environm...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $260K *

Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $96K *

Join a team that's dedicated to advancing anesthesiology practices, promoting CRNA autonomy in a supportive environment. Engage in diverse cases at a Level II trauma center while enjoying a flexible d...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Lead a dynamic anesthesiology team in a Level II trauma center, ensuring high-quality patient care and promoting CRNA autonomy. Collaborate effectively with anesthesiologists while managing diverse ca...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$175K - $200K *

Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$198K - $297K *

Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$115K - $135K *

Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $125K *

Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Pioneer in radiology innovation by enhancing clinical value and technology. Join a forward-thinking team that prioritizes high-quality patient care while driving improvements in service and operationa...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Elevate patient care by managing complex cases in collaboration with healthcare teams. Utilize your expertise to assess, diagnose, and implement treatment plans, ensuring optimal outcomes in an outpat...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$240K - $300K *

Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $167K *

Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Take ownership of patient care by assessing, diagnosing, and treating individuals. Collaborate with physicians to develop care plans, educate patients, and ensure quality health services in a supporti...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$173K - $205K *

Shape the future of neurology by leading in vivo pharmacology studies, collaborating with cross-functional teams, and driving data-driven decisions for IND submissions in a dynamic biotech environment...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $140K *

Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$220K - $250K *

Shape the future of neurology by building partnerships with Medical Experts, generating insights, and collaborating across teams to enhance patient care and drive innovation in a dynamic healthcare la...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$260K - $270K *

Unlock your potential as a Psychiatrist, providing advanced outpatient care via virtual platforms. Collaborate with multidisciplinary teams to deliver comprehensive treatment for diverse psychiatric c...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$268K - $466K *

Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.