Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$85K - $100K *

Help us optimize Epic applications by leading projects, troubleshooting issues, and ensuring seamless integration. Collaborate with teams to enhance workflows and provide expert support, all while mai...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $150K *

Lead the charge in integrating complex hospital data systems into Astra OS. Own end-to-end data pipelines, collaborate with customers, and design scalable solutions that enhance healthcare operations...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$190K - $225K *

Empower commercial strategies by building relationships with key thought leaders in rare neurological diseases, capturing insights to inform brand development and launch planning, and ensuring impactf...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Empower your career by joining a dedicated clinical team providing psychological services in long-term care. Enjoy professional autonomy, a flexible schedule, and robust support while making a meaning...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $159K *

Drive privacy excellence by executing assessments and managing risks across products. Collaborate with Legal, Product, and Engineering to embed privacy by design and enhance frameworks that protect cu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K *

Elevate your career by providing clinical support and training for patient monitoring systems. Lead implementation teams, ensure customer satisfaction, and maintain clinical expertise while managing t...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $105K *

Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$174K - $374K *

Strategize clinical oversight and drive innovative medical management programs. Collaborate with a multidisciplinary team to enhance member care outcomes while representing the organization to externa...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower the clinical support team by coordinating complex cases, mentoring junior counselors, and enhancing protocols. Your expertise will drive effective communication and quality standards in geneti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Join a team that's dedicated to enhancing patient care in cardiology. This role involves providing comprehensive support, education, and coordination for patients with cardiovascular conditions, ensur...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$270K - $280K *

Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Lead the charge in driving sales growth by engaging independent physician practices. Utilize your expertise in full-cycle sales to build relationships, conduct virtual demos, and collaborate with team...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$184K - $253K *

Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Elevate your career by leading financial planning and analysis, managing budgets, and driving strategic insights. Collaborate with cross-functional teams to enhance operational performance and deliver...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Serve as a Medical Director managing innovative care models and policies to enhance patient outcomes, collaborating with teams across two facilities to ensure high-quality medical services and adheren...

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$210K *

Unlock potential by joining our telemedicine team, where you'll provide compassionate, patient-centered care across Iowa. Enjoy flexible scheduling while managing diverse clinical cases through secure...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Join a team that's redefining healthcare delivery through telemedicine. Provide high-quality, patient-centered virtual care across Iowa, managing diverse clinical cases while enjoying a flexible sched...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Empower compliance excellence by leading audits, risk assessments, and investigations. Collaborate with teams to ensure adherence to healthcare regulations and promote ethical practices while adapting...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$68K - $103K *

Shape the future of revenue cycle management by driving process improvements and reducing denials. Collaborate with teams to analyze trends, implement best practices, and enhance client satisfaction t...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.