Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$66K - $189K *

Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$177K - $338K *

Help us advance women's health through innovative clinical trial strategies, where you will conduct, support, and report on global studies for cutting-edge compounds, ensuring adherence to regulatory...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate clinical operations by managing staff, ensuring compliance, and enhancing patient satisfaction in a dynamic wound healing center. Drive efficiencies and oversee daily functions while fostering...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$170K - $200K *

Unlock potential by providing strategic legal counsel on clinical and commercial operations, focusing on regulatory compliance, privacy, and data protection in a dynamic biopharmaceutical environment...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Healthcare

$140K - $270K *

Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$320K - $500K *

Join a dynamic clinical team as a psychiatrist, providing 100% outpatient care with flexible scheduling. Enjoy a supportive environment, competitive compensation, and a focus on work/life balance whil...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$300K - $350K *

Empower your career by evaluating and treating patients with cardiac and thoracic conditions. Perform surgical procedures, mentor colleagues, and respond to emergencies while providing exceptional pat...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Manage and lead the Nursing team to ensure safe, quality, family-centered patient care. Oversee operations, budget, and staff development while collaborating with interdisciplinary teams to enhance pa...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$153K - $268K *

Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $190K *

Join a team that's driving excellence in clinical operations, leading global studies and ensuring regulatory compliance. Utilize your project management expertise to enhance efficiency and maintain hi...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$148K - $256K *

Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform healthcare outcomes by leveraging clinical expertise to review medical records, ensuring compliance with government standards while fostering collaboration and maintaining confidentiality in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$174K - $374K *

Unlock potential by leading medical management initiatives remotely, supporting member needs and optimizing clinical services for optimal care. Leverage your expertise in Orthopedic Spine or Neurosurg...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the charge in enhancing rehab services by supervising a multidisciplinary team, ensuring compliance, and driving clinical excellence in a skilled nursing facility setting. Collaborate with manage...

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $140K *

Accelerate the growth of colorectal cancer screening solutions by engaging healthcare providers and driving product adoption. Collaborate with partners while strategically planning to maximize market...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $180K *

Empower growth in healthcare by expanding product use and training staff. Collaborate across teams to launch innovations and build valuable relationships, enhancing critical care capabilities in your...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Transform healthcare analytics by supporting ACOs in the MSSP program. Leverage data-driven insights to track performance metrics, optimize risk scores, and collaborate with teams to enhance value-bas...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $235K *

Drive growth by leveraging your consultative sales expertise to engage higher education leaders, aligning their needs with innovative research solutions while managing client relationships and achievi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$199K - $321K *

Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Empower patients to achieve optimal physical health by evaluating needs, creating tailored care plans, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcome...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.