Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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$110K - $130K *

Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $180K *

Architect scalable Generative AI solutions using AWS tools, focusing on LLMs, RAG, and agent-based workflows. Collaborate with teams to ensure performance and cost efficiency while guiding implementat...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Drive the transformation of AI solutions by developing, deploying, and optimizing machine learning models. Collaborate with stakeholders to create innovative applications that enhance patient care whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$175K - $195K *

Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $180K *

Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Drive impactful decision-making and support for EHRM initiatives, enhancing operational efficiency and stakeholder engagement through strategic analysis, project management, and effective communicatio...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$155K - $410K *

Advance cutting-edge AI solutions through innovative data strategies, guiding teams to transform raw data into actionable insights while overseeing project delivery and client engagement in a dynamic...

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$155K - $410K *

Shape the future of data-driven insights by leading AI and machine learning projects. Inspire teams, engage with executives, and drive business growth while developing innovative solutions that transf...

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$152K - $190K *

Elevate quality assurance within AI solutions by leading test efforts, validating products, and enhancing automated frameworks to deliver reliable, compliant, and high-performing technology that meets...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $200K *

Transform engineering practices by leading measurement systems and pipeline equipment initiatives. Shape standards, enhance reliability, and develop a skilled team to ensure the safety and performance...

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$172K - $203K *

Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $95K *

Drive seamless M&A integration by managing seller data workflows, ensuring accuracy and readiness for Day 1 operations. Develop key skills in data management and process optimization to grow into a br...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$83K - $140K *

Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$171K - $190K *

Unlock potential by leading the design and implementation of scalable data platforms. Drive innovation in cloud data architecture and pipeline automation, collaborating across teams to deliver impactf...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join us to manage and enhance our consumer purchase data assets, collaborating with vendors and internal teams to ensure high-quality data acquisition and compliance, driving insights and analytics fo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $100K *

Lead the charge in overseeing early phase clinical trials, providing statistical expertise and ensuring compliance with regulatory standards while collaborating with clients and stakeholders to delive...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate customer insights by analyzing complex data to drive retention strategies. Collaborate with senior leaders to present actionable recommendations that enhance customer experience and operationa...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$158K - $170K *

Lead the development of predictive models integrating advanced ML techniques to drive strategic decision-making across credit risk, collections, and business operations while mentoring data scientists...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$188K - $235K *

Develop AI-powered systems from concept to production, collaborating with clients to identify needs, prototype solutions, and ensure quality. Engage closely with users to iterate and enhance product f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $225K *

Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$207K - $300K *

Drive reliability and performance in large-scale systems by leading innovative infrastructure projects and collaborating with development teams to enhance Google Ads services and ensure optimal uptime...

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.