Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.
Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.
Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.
Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.
Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.
Software Engineer - AI Accelerated Development
$110K - $130K *
Innovate and drive AI agent development for clinical trial platforms, integrating LLMs through the .NET stack. Engage in hands-on engineering to deliver end-to-end AI features, enhancing patient-centr...
Reposted 3 weeks ago
$110K - $130K *
Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...
6 days ago
Technical Architect - ML - GenAI
$150K - $180K *
Architect scalable Generative AI solutions using AWS tools, focusing on LLMs, RAG, and agent-based workflows. Collaborate with teams to ensure performance and cost efficiency while guiding implementat...
Reposted 1 week ago
$120K - $145K *
Drive the transformation of AI solutions by developing, deploying, and optimizing machine learning models. Collaborate with stakeholders to create innovative applications that enhance patient care whi...
1 week ago
$175K - $195K *
Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...
1 week ago
Data Engineer | VA Claims Modernization
$120K - $180K *
Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...
1 week ago
$80K - $95K *
Drive impactful decision-making and support for EHRM initiatives, enhancing operational efficiency and stakeholder engagement through strategic analysis, project management, and effective communicatio...
Today
AI & GenAI Data Scientist-Director
$155K - $410K *
Advance cutting-edge AI solutions through innovative data strategies, guiding teams to transform raw data into actionable insights while overseeing project delivery and client engagement in a dynamic...
Reposted 3 weeks ago
AI & GenAI Data Scientist-Director
$155K - $410K *
Shape the future of data-driven insights by leading AI and machine learning projects. Inspire teams, engage with executives, and drive business growth while developing innovative solutions that transf...
Reposted 3 weeks ago
Lead AI Quality Assurance Engineer
$152K - $190K *
Elevate quality assurance within AI solutions by leading test efforts, validating products, and enhancing automated frameworks to deliver reliable, compliant, and high-performing technology that meets...
Reposted 2 weeks ago
Manager Pipeline and Measurement Engineering
$140K - $200K *
Transform engineering practices by leading measurement systems and pipeline equipment initiatives. Shape standards, enhance reliability, and develop a skilled team to ensure the safety and performance...
1 week ago
Senior ML Data Scientist - Women's Health
$172K - $203K *
Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...
2 weeks ago
$92K - $110K *
Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...
3 weeks ago
Integration and Data Management Analyst
$90K - $95K *
Drive seamless M&A integration by managing seller data workflows, ensuring accuracy and readiness for Day 1 operations. Develop key skills in data management and process optimization to grow into a br...
Reposted 2 days ago
$83K - $140K *
Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...
Yesterday
$171K - $190K *
Unlock potential by leading the design and implementation of scalable data platforms. Drive innovation in cloud data architecture and pipeline automation, collaborating across teams to deliver impactf...
3 weeks ago
Data Acquisition Specialist – CPG Purchase Data
$80K - $95K *
Join us to manage and enhance our consumer purchase data assets, collaborating with vendors and internal teams to ensure high-quality data acquisition and compliance, driving insights and analytics fo...
4 days ago
$85K - $100K *
Lead the charge in overseeing early phase clinical trials, providing statistical expertise and ensuring compliance with regulatory standards while collaborating with clients and stakeholders to delive...
2 days ago
Senior Analyst, Advanced Analytics, Cross-USRM Analytics
$95K - $115K *
Elevate customer insights by analyzing complex data to drive retention strategies. Collaborate with senior leaders to present actionable recommendations that enhance customer experience and operationa...
Today
$120K - $145K *
Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...
1 week ago
Manager, Predictive Modeling and Machine Learning
$158K - $170K *
Lead the development of predictive models integrating advanced ML techniques to drive strategic decision-making across credit risk, collections, and business operations while mentoring data scientists...
Reposted 4 weeks ago
Sr. Software Engineer - Customer Facing Applied AI
$188K - $235K *
Develop AI-powered systems from concept to production, collaborating with clients to identify needs, prototype solutions, and ensure quality. Engage closely with users to iterate and enhance product f...
2 weeks ago
Senior Machine Learning (ML) Engineer (CCC Casualty / Claims Intelligence)
$180K - $225K *
Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...
Yesterday
Senior Machine Learning Engineer (Traditional ML & Financial Data) - Remote - USA
$125K - $150K *
Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...
Reposted 2 days ago
Staff Site Reliability Engineer, AQI Data SRE
$207K - $300K *
Drive reliability and performance in large-scale systems by leading innovative infrastructure projects and collaborating with development teams to enhance Google Ads services and ensure optimal uptime...
1 week ago
What kinds of high-paying jobs can I find in Pennsylvania?
Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.
Which Pennsylvania cities have professional job opportunities?
Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.
Do Pennsylvania jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.
How can I narrow my search for jobs in Pennsylvania?
Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.
Are remote or hybrid jobs available in Pennsylvania?
Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.