Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$157K - $238K *

Pioneer innovative threat detection engineering solutions that protect our infrastructure. Collaborate across teams to enhance our detection platform through advanced telemetry, improve pipeline relia...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$73K - $110K *

Analyze coding quality data and support compliance initiatives to enhance hospital coding accuracy. Collaborate with teams to develop guidance and conduct audits, ensuring adherence to regulatory stan...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $126K *

Lead and optimize subcontract management by negotiating agreements, ensuring compliance, and collaborating with stakeholders to drive successful federal contracting outcomes while mentoring junior sta...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Transform the data platform by owning product direction and delivery. Collaborate across teams to prioritize needs, streamline processes, and ensure engineering focuses on impactful projects while enh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $158K *

Transform data engineering processes by building and optimizing scalable ETL pipelines in a dynamic environment, contributing to critical Oracle ERP projects ensuring compliance and data integrity for...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$200K - $225K *

Drive the design and delivery of innovative AI-driven applications. Oversee the full development lifecycle, ensuring scalability and reliability in multi-tenant enterprise solutions while collaboratin...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$180K *

Drive AI innovation by designing and scaling enterprise solutions that enhance business outcomes. Collaborate with cross-functional teams to ensure secure, compliant, and effective AI implementations...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Lead the end-to-end recruiting process, enhancing strategies and partnerships across departments. Drive high-volume hiring with autonomy, ensuring a seamless candidate experience while collaborating c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$122K - $187K *

Drive transformative sales for leading Google Cloud solutions, guiding clients through technology transformations. Collaborate with cross-functional teams to build relationships and deliver impactful...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$75K - $158K *

Transform business objectives into actionable insights by leveraging Agile methodologies. Collaborate with cross-functional teams to refine backlogs, create user stories, and ensure alignment between...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Empower cross-functional teams by analyzing requirements, facilitating Agile processes, and ensuring alignment between business goals and technical execution. Drive effective backlog management and su...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Empower cross-functional teams as a Business Analyst, driving Agile practices, refining backlogs, and aligning business objectives with technical execution to enhance project outcomes and stakeholder...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K *

Shape the future of business analysis by connecting program needs with technical solutions. Leverage your Salesforce expertise to enhance workflows, gather requirements, and collaborate with stakehold...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Engineer your career by leading Oracle Fusion data conversions from legacy systems. Collaborate with finance SMEs and AI agents to ensure accurate data mapping, error resolution, and reconciliation fo...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $175K *

Transform your career by engaging with federal clients, driving enterprise solutions, and building lasting relationships in a dynamic SaaS environment. Leverage your technical expertise to exceed sale...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Transform multi-channel campaign strategies to drive client success. Manage audience logic, funnel progression, and clear business objectives while balancing multiple strategies and ad-hoc requests ef...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$118K - $216K *

Lead the development of innovative ad solutions for a high-traffic mobile app, enhancing user experience while driving revenue. Collaborate with cross-functional teams to implement AI-driven workflows...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$170K - $190K *

Lead the charge in advancing analytical development strategies for small molecule drug substances and products, ensuring compliance and quality across the product lifecycle while collaborating with cr...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform identity and access management by executing daily operations, supporting AI tooling, and managing SaaS vendor administration. This role offers hands-on experience and a clear growth path tow...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $293K *

Shape the future of workforce transformation by designing AI-enabled solutions that enhance talent strategies, skills development, and organizational readiness for an evolving work landscape. Drive ch...

2 days ago

  •   5 - 7 years exp.  •   Business Services

$134K - $205K *

Drive modernization of nuclear power plants by leading and supporting control projects, coordinating across disciplines, and ensuring technical execution to enhance operational efficiency and client s...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$128K - $135K *

Drive impactful insights by transforming data into strategic decisions that enhance retail partnerships. Collaborate with key stakeholders to deliver analytics that support growth and optimize perform...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Accelerate your career by driving revenue growth with enterprise clients. Leverage your sales expertise in the fashion industry to build relationships, identify needs, and deliver tailored solutions t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$79K - $109K *

Transform financial operations by owning monthly close processes, ensuring accurate COGS and accruals. Collaborate with leadership to drive data-driven decisions in a dynamic, growth-stage tech enviro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.