Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$207K - $290K *

Elevate your career by leading a dynamic Applied AI team, transforming innovative AI solutions into production-ready systems within a regulated financial environment, while collaborating across depart...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $175K *

Pioneer insights at the intersection of Sales, Marketing, and CS by owning and enhancing analytical infrastructure to generate decision-ready insights that drive growth in a dynamic, fast-paced enviro...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform the engineering landscape by owning architecture, deployment, and incident management. Collaborate with teams to prioritize features, enhance payment systems, and integrate AI, all while ens...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Drive enterprise growth by strategically engaging high-value accounts, orchestrating complex sales processes, and leveraging AI capabilities to enhance compliance workflows. Build executive relationsh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$219K - $285K *

Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Empower growth by owning strategic partnerships, driving go-to-market plans, and ensuring compliance. Collaborate across teams to enhance revenue and strengthen relationships, while managing budgets a...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $140K *

Lead system enhancements and process improvements for HRIS, focusing on optimizing functionalities and automating workflows to support HR initiatives. Collaborate with cross-functional teams to align...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Drive growth and satisfaction by managing client relationships in Life Sciences. Oversee the sales process, collaborate with experts, and leverage insights to uncover new opportunities while ensuring...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Optimize customer engagement by architecting automated workflows and data-driven insights. Collaborate with teams to enhance communication strategies and drive measurable outcomes, ensuring a seamless...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$140K - $175K *

Develop innovative software solutions that enhance access to mental and physical health services. Collaborate with cross-functional teams to deliver reliable applications, ensuring quality and perform...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $229K *

Lead the design and development of AI-driven solutions within SAP S/4HANA, integrating advanced AI technologies to drive business transformation and innovation across enterprise environments. Mentor t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Empower ecommerce brands to leverage AI marketing tools effectively, guiding users to understand and implement solutions that enhance their growth strategies while fostering confidence in AI capabilit...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the development of our observability practice, creating dashboards and alerting systems to ensure uptime and reliability across enterprise tools. Build visibility from scratch, automate processes...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$215K - $235K *

Lead the charge in developing scalable enablement programs that enhance sales performance across customer-facing roles. Utilize your expertise in instructional design and AI to drive adoption, retenti...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $137K *

Unlock potential by leading strategic client relationships to drive revenue growth and retention. This high-impact role requires expertise in digital media and AI tools, fostering executive partnershi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$204K - $254K *

Lead technical engagements with customers, driving product success through demos, presentations, and collaboration with sales. Contribute to a high-growth team focused on innovative solutions and cust...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$137K - $231K *

Empower your career by shaping design systems that enhance user experience. Collaborate with teams to build high-quality, interactive UI across platforms, ensuring accessibility and performance while...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$156K - $275K *

Lead the charge in shaping the technical strategy for reliability and infrastructure. Drive initiatives across teams, design scalable systems, and enhance operational excellence while mentoring engine...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$75K - $95K *

Elevate mobile app acquisition strategies by managing omni-channel paid media campaigns. Collaborate with clients to optimize performance, drive growth, and ensure seamless execution across platforms...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Media

$130K - $200K *

Drive impactful design and development of front-end features, owning the code from concept to production. Collaborate with teams to establish design systems and set direction for user-centric products...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $140K *

Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in developing scalable audience solutions by integrating predictive models and data workflows. Collaborate with cross-functional teams to enhance audience activation and ensure reliabl...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$100K - $231K *

Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K *

Shape the future of non-profit engagement by leading sales initiatives, driving pipeline growth, and fostering client relationships. Leverage your strategic sales expertise to elevate our impact and a...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$96K - $181K *

Lead the transformation of enterprise technology by architecting scalable GCP solutions and guiding cross-functional teams in developing robust AI-driven applications. Drive innovation through hands-o...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.