Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$63K - $169K *

Optimize customer engagement solutions by architecting enterprise-scale systems using Adobe technologies. Collaborate with stakeholders to drive innovative omnichannel experiences and ensure alignment...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Unlock potential by joining a dynamic Global SRE team focused on enhancing software reliability and observability. Collaborate with teams to implement best practices and innovative solutions, ensuring...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the charge in designing and optimizing scalable data pipelines and infrastructure, ensuring efficient data processing and delivery to support agency missions. Collaborate with cross-functional te...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Drive your career with a role focused on designing and optimizing data pipelines and infrastructure. Collaborate with cross-functional teams to enhance data delivery and support the agency's mission t...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$123K - $197K *

Transform the landscape of AI by architecting and optimizing cutting-edge LLMs while collaborating with diverse tech teams to innovate and enhance applications for performance and accuracy in resource...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$75K - $90K *

Drive cross-functional collaboration and optimize supply chain processes by leading SIOP initiatives. Utilize data analytics to enhance demand planning, inventory management, and financial alignment...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$75K - $90K *

Join a team that's transforming supply chain planning through data-driven insights and cross-functional collaboration. Your expertise will enhance demand forecasting, inventory management, and strateg...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $83K *

Transform the future of engineering by applying your skills in a dynamic team. Collaborate on diverse projects, utilize advanced software, and contribute to innovative solutions that shape the built e...

4 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$66K - $105K *

Help us optimize financial performance through advanced analysis and modeling. Collaborate with business leaders on budgeting, forecasting, and strategic initiatives, providing insights to drive reven...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Drive mobile engineering excellence by leading app development, mentoring engineers, and integrating AI solutions to enhance user experiences across iOS and Android platforms while collaborating with...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$180K - $215K *

Lead the design and development of AI-driven acquisition systems, creating automated workflows and optimizing audience targeting to enhance customer engagement and retention in a data-rich environment...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$250K - $400K *

Shape the future of AI by designing evaluation frameworks and feedback systems that enhance model performance. Collaborate across teams to translate research into scalable solutions, driving impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$158K - $190K *

Elevate client engagement by driving complex technology sales, managing a $20M+ target, and collaborating with senior leaders to build strategic relationships and deliver impactful solutions across di...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$95K - $115K *

Unlock your potential by managing clinical data for impactful research. Collaborate with multidisciplinary teams to design databases, ensure compliance, and deliver high-quality data management soluti...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Advance your career by driving new business growth across North America. Build strategic relationships with senior leaders in AI and technology, leading complex enterprise sales cycles and delivering...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $160K *

Empower your career as a Principal IAM Engineer, owning the identity control plane and ensuring secure access to sensitive data. Collaborate with cross-functional teams to automate identity processes...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $215K *

Lead innovative PR strategies to elevate brand visibility through dynamic storytelling, leveraging data insights and engaging fan experiences within a premier partnership, all in a fast-paced environm...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $160K *

Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $250K *

Drive your career with a strategic role that shapes customer growth through data insights. Collaborate with cross-functional teams to optimize the growth funnel, influence product direction, and enhan...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $105K *

Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $100K *

Join a dynamic team as a Senior Strategist, where you'll lead data-driven strategies, mentor talent, and drive innovative solutions in healthcare advertising. Collaborate with creative teams to enhanc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$133K - $184K *

Join a team that's enhancing threat detection and response capabilities. As a hands-on technical leader, you'll drive security initiatives across cloud, infrastructure, and identity platforms, while m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$153K - $208K *

Partner with us to architect and execute integrated marketing campaigns that drive enterprise product launches and enhance brand storytelling, ensuring alignment across multiple teams and channels for...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $160K *

Lead strategic banking initiatives by leveraging your enterprise sales expertise to build relationships and drive new business within Tier 1 global banks, shaping our go-to-market strategy and establi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.