Senior Staff, Software Engineer

DELFI Diagnostics, Inc.

$185K — $260K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in Computer Science, Mathematics, Data Science, or related field
  • 10+ years of professional experience (BS), 8+ years (MS), or 5+ years (Ph.D.)
  • Excellent verbal and written communication skills
  • Exposure to the life sciences, DNA sequencing, or bioinformatics
  • Demonstrated experience in setting long-term technical strategy
  • Advanced knowledge of scalable cloud computing infrastructures (preferably AWS)
  • Expertise in Python and proficiency in at least one compiled language (e.g., Rust, Java, C++, C#)
  • Strong software design and data integration skills
  • Command of agile practices, Jira, Git, and CI/CD pipelines

Responsibilities

  • Set long-term technical strategy for bioinformatics systems
  • Lead system architecture and complex design reviews
  • Design data integration architecture between systems
  • Establish engineering best practices and SDLC standards
  • Drive risk analysis and verification strategies for regulated software
  • Architect DevOps strategy ensuring reliability and compliance
  • Collaborate with cross-functional teams to implement production software
  • Mentor engineers and cultivate future technical leaders
  • Act as a technical authority, influencing product direction across teams

Benefits

  • Flexible time-off policy
  • 401(k) retirement plan
  • Comprehensive medical, dental, and vision coverage
  • Onsite lunch three days a week
  • Wellness-related offerings
Full Job Description
About the role

In this role, you'll be a senior technical leader on our bioinformatics pipeline team, contributing to long-term technical direction and architectural decisions for major systems with a focus on software and cloud architecture. You'll partner across Engineering, Data Science, R&D, Regulatory, and Project Management to translate strategy into executable technical plans.

This role sits at the intersection of deep technical expertise, design control rigor, and cross-functional leadership. We seek a leader who can hold the long view while still going deep on the hardest technical problems, and who elevates the team through the standards and systems they build.

What you'll do

Strategy & Architecture
  • Set long-term technical strategy and architectural vision for our bioinformatics pipeline systems, ensuring today's decisions support tomorrow's product roadmap.
  • Lead system architecture and high-stakes design reviews end-to-end, guiding the team through the most complex technical tradeoffs.
  • Design and own data hand-off and integration architecture between software systems.

Engineering Standards & Process
  • Serve as a leader in engineering best practices-establishing standards, driving software-development lifecycle (SDLC) rigor, and setting the bar for code quality, testing, and design across the team.
  • Drive requirements engineering, risk analysis, and verification strategies for regulated software components.
  • Partner with staff engineers on test design and execution, driving excellence in SDLC process implementation.

Operations & Delivery
  • Architect and own the DevOps strategy for the pipeline team, including cybersecurity, CI/CD, infrastructure-as-code, deployment automation, observability, and environment management, ensuring reliability and compliance in a regulated context.
  • Work with data scientists, lab staff, and other stakeholders to implement production software for diagnostic applications.

Leadership
  • Partner with our Program Management team and engineering leadership on roadmap planning, milestone definition, resourcing, dependency management, and risk tracking across multi-quarter initiatives.
  • Mentor and develop staff and senior engineers, raising the team's technical ceiling and cultivating the next generation of technical leaders.
  • Serve as a recognized technical authority across the organization, influencing product and platform direction without direct authority over teams or roadmaps.


What you'll bring

Required
  • Bachelor's degree in Computer Science, Mathematics, Data Science, or related field
  • Relevant professional experience dependent on level of education:
    • BS: 10+ years, MS: 8+ years, Ph.D: 5+ years
  • Excellent verbal and written communication skills, including proficiency in public speaking and technical presentation
  • Exposure to the life sciences industry, including DNA sequencing, quantitative genetics, bioinformatics, or data science
  • Demonstrated experience setting long-term technical strategy and architectural standards across multi-team or multi-system scope
  • Advanced knowledge of cloud computing infrastructure design and implementation for scalable high-performance computing applications (AWS preferred)
  • Expertise in Python and strong proficiency in at least one compiled language (Rust, Java, C++, or C#)
  • Strong software design skills
  • Experience designing data integration patterns and contracts between software systems
  • Strong command of agile development practices, Jira, Git, and modern CI/CD pipelines

Preferred
  • Working knowledge of regulated software development standards (IEC 62304, ISO 13485, FDA 21 CFR Part 11, and ISO 14971)
  • Experience working at an early-stage or high-growth company where the environment moves fast


$185,000 - $260,000 a year

Actual base pay will consider experience, skillset, education, and geography. This role may be eligible for other forms of compensation, including an annual bonus and a new hire equity grant, subject to the terms of the applicable plans and Company discretion. All employees are also eligible for DELFI's comprehensive and competitive benefits package, including but not limited to: a flexible time-off policy; a 401(k) retirement plan; an extremely competitive medical, dental, and vision coverage; onsite lunch 3 days a week; and other wellness related offerings.

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