Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biotherapeutics R&D
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:We are searching for the best talent for a
Senior Scientist, In-vivo CAR-T, to be based on-site in Spring House, PA.
Purpose:The Senior Scientist will support the development, optimization, and scale-up of lentiviral vector (LVV) drug product processes from early to late-stage development. The role combines hands-on laboratory work with strong cross-functional collaboration to ensure robust, scalable, and GMP-ready processes.
Key Responsibilities:- Design and execute LVV process development studies across early and late development stages
- Collaborate with modelling experts, data scientists to identify opportunities where modelling or machine learning can reduce experimental burden, improve robustness, or define process design space.
- Perform hands-on laboratory work including process design, optimization, and characterization
- Analyze and interpret data to support process understanding, optimization, and decision-making
- Support process characterization activities, including identification of CPPs and development of robust processes
- Contribute to scale-up and manufacturing readiness, including support of technology transfer to internal sites or CMOs
- Collaborate cross-functionally with Analytical Development, MSAT, Quality, Manufacturing, and Regulatory teams to ensure alignment on process strategy and execution
- Document experimental work and results in accordance with GxP and data integrity requirements
- Participate in troubleshooting activities and continuous process improvement initiatives
Qualifications:Required:- Ph.D. 0-2 years' experience, B..S. or M.S. with 4-6 years' experience in an appropriate scientific discipline (Life Sciences or Chemical Engineering) is required
- Relevant experience in process development of viral vectors and/or LVV formulation development
- Strong hands-on laboratory experience in drug product or viral vector development
- Understanding of process scale-up, technology transfer, and GxP principles
- Strong scientific problem-solving and data interpretation skills
- Hands-on, proactive, and detail-oriented approach
- Ability to work effectively in a cross-functional, matrixed environment
- Clear and concise communication skills (written and verbal)
- Ability to manage multiple priorities in a dynamic development environment
Preferred:- Experience with LVV platforms, viral vectors and/or advanced therapies
- Familiarity with process validation (e.g., LCPV) and manufacturing support
- Exposure to both early and late-stage development or commercial readiness activities
Required Skills: Preferred Skills:Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Consulting, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Pharmacogenetics, Pharmacovigilance, Process Improvements, Quality Assurance (QA), Relationship Building, Research Documents, Scientific Research, Technologically Savvy
