Job Description Summary
Job Title: Senior Scientist I or II, Oligonucleotide Chemistry and Innovation

#LI-Onsite

Location: Cambridge, USA

Relocation Support: This role is based in Cambridge, USA. Novartis is unable to offer relocation support: please only apply if accessible.

Job Description

Key Responsibilities

• Execute solid-phase synthesis of therapeutic oligonucleotides using automated DNA and RNA synthesizer platforms.
• Purify and characterize oligonucleotides using chromatographic and mass spectrometry-based analytical techniques.
• Develop and optimize synthesis, purification, and analytical methods to improve efficiency and product quality.
• Operate, troubleshoot, and maintain critical laboratory instrumentation to ensure reliable data generation.
• Identify and implement innovative oligonucleotide chemistries to advance RNA therapeutic discovery programs.
• Analyze, interpret, and present experimental results to multidisciplinary scientific teams and stakeholders.
• Maintain accurate electronic laboratory records and support reproducible, high-quality scientific practices.

Essential Requirements

• Bachelor of Science or Master of Science in Chemistry or a related scientific field.
• Significant hands-on experience in oligonucleotide synthesis and conjugation within an academic or industry setting.
• Demonstrated expertise using automated DNA and RNA synthesizer platforms.
• Experience purifying and characterizing oligonucleotides using chromatographic and mass spectrometry techniques.
• Strong data analysis, documentation, and scientific presentation skills.
• Proven ability to thrive in a collaborative, fast-paced research environment while managing multiple priorities.

Desirable Requirements

• Doctor of Philosophy in Chemistry or a closely related scientific discipline.
• Experience developing and optimizing methods incorporating specialty phosphoramidite building blocks.
• Expertise with high-resolution liquid chromatography and mass spectrometry analytical techniques for oligonucleotide characterization.
• Experience supporting the discovery and development of RNA therapeutics, including small interfering RNA and antisense oligonucleotides.
• Exposure to high-throughput oligonucleotide synthesis workflows and process innovation.
• Demonstrated ability to work independently with urgency, accountability, and strong organizational skills.

Rewards

At Novartis, we're committed to reimagining medicine together - and rewarding the people who make it happen.

The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and a minimum of 14 weeks paid parental leave.

Expected Annual Base Salary Range for role:

• US: 93,800.00 - 174,200.00 USD Annual

The salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Further details will be provided during the application process.

Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.

Read our brochure to learn more about our global total rewards offering: https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf

Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process.

Salary Range
$93,800.00 - $174,200.00

Skills Desired
Analytical Chemistry, Automation, Chemical Analysis, Chemical Laboratory, Chemical Synthesis, Chemistry, Creativity, Curious Mindset, Data Analysis, Drug Development, Innovation, Medical Research, Medicinal Chemistry, Organic Chemistry, Pharmaceutical Industry, Science, Team Player