Job Description

Immunology Discovery is currently seeking a motivated, independent, versatile, and detail-oriented Sr. Scientist with a passion for improving patient lives to support internal discovery efforts at our Research Division in San Diego, CA. The Sr. Scientist will work in a matrixed environment with a focus on preclinical IND-enabling studies, and translational studies enabling indication prioritization and rationale for combination therapies.  The optimal candidate will possess the ability to work independently and lead cross-functional teams.

Main job duties include, but are not limited to:

• Working with team leaders to develop strategy and drive drug discovery and translational medicine discovery programs forward

• Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification in the preclinical and IND-enabling space

• Develop and run cell-based assays to characterize drug target pathway activity or PD biomarkers in primary cells derived from patient samples

• Analyze, critically interpret data and share results to project teams as required

• Collaborate with bioinformatics and translational team members to generate datasets and identify biomarkers supporting translational medicine

• Keep meticulous records of experiments performed and maintain lab notebook entries

• Represent Immunology Discovery in working groups and/or project teams

• Work collaboratively with other scientists in Immunology Discovery in a highly matrixed lab environment

QUALIFICATIONS:

Education:

• PhD in immunology, cell biology, or related biomedical science and relevant academic and/or industry experience

• MS in immunology, cell biology, translational research or related biomedical science and at least five (5) years of relevant industry experience

• BA in immunology, cell biology, translational research or related biomedical science and at least eight (8) years of relevant industry experience

Required Experience and Skills:

• Strong cell culture skills including cell lines and primary cells

• Experience in multi-color flow cytometry to immunophenotype human cells (from blood or tissues), assess immune response or cell signaling pathways

• Experience developing ex-vivo cell-based assays to assess immune responses from human whole blood, PBMCs, and various immune cell subsets

• Experience with immunoassay platforms (e.g., ELISA, Meso Scale Discovery) to measure analytes in serum, plasma, supernatant or cell lysates

• Proficiency in data analysis using Excel, Prism (GraphPad), FlowJo

• Independent self-motivated life scientist who can generate scientific questions and design experiments to address them

• Scientific rigor and curiosity to address scientific questions and design experiments to test working hypotheses

• Excellent problem-solving and organizational skills

• Strong communication and interpersonal skills with an eagerness to work with and support colleagues across the organization in a matrixed environment

Preferred Experience and Skills:

• Experience in spectral flow cytometry

• Experience with molecular/ cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation

• Experience in NGS platforms

• Understanding of the drug discovery process with industry experience

• Understanding of immune diseases, including current research and drugs in development

• Experience in developing and running transcriptomics experiments (bulk and single cell RNAseq)

• Background in biomarker discovery and development

#EligibleforERP 

Required Skills:

Preferred Skills:

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