Job Title: Senior Scientist Genomic Medicine BioAnalytics Characterization
Main responsibilities: - Develop and implement advanced characterization strategies for gene therapy candidates, including viral vectors and nonviral particles
- Utilize a robust and sensitive LC-MS platform to profile HCP clearance throughout purification process and quantitatively monitor impurities of concern to support CMC product development
- Establish HCP impurity method detection limits and precision, and oversee transfer and comparability to automated sample preparation methods within facility
- Utilize LC-MS proteomics platform in profiling differential protein expression in cell lysates to support Cell Culture Process Development
- Develop LC-MS characterization methods of nonviral particles including RNA impurity determination and oligonucleotide mapping
- Collaborate cross functionally and support process/formulation development through comprehensive LC-MS characterization (peptide mapping, HCP analysis, and oligonucleotide analysis)
- Establish new end-to-end automated data workflows (e.g. from data upload and application specific data processing to reporting in ELN)
- Author technical documentation including reports, protocols, and regulatory filings (IND/IMPD/BLA)
- Contribute to scientific literature and present at internal and external conferences
About You:Education:
- Ph.D. in Biochemistry or Chemistry-life science related field, OR
- M.S. with 4+ years of industry experience
Experience & Technical Skills:
- Extensive LC-MS experience in protein characterization, identification and protein quantitation
- Proficiency with Thermo and/or AbSciex instruments and at least one peptide mapping/proteomics software such as Spectronaut, Genedata Expressionist, Protein Metrics, Skyline, or Proteome Discoverer
- Demonstrated success implementing novel analytical technologies
Preferred Qualifications:
- Experience with automation and AI-driven analytical workflows is highly desirable.
Professional Skills:
- Excellent organizational and problem-solving abilities
- Strong interpersonal and communication skills
- Ability to work collaboratively in cross-functional teams
Why Choose Us:- Bring the miracles of science to life alongside a supportive, future focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave
- Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
- Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.
- Help improve the lives of millions of people globally by making drug development quicker and more effective.
The salary range for this position is:
$100.500,00 - $145.166,66
All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
