Pfizer

Senior Principal Scientist, Process Chemistry

Pfizer$124K — $207K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • PhD in Organic Chemistry with 8+ years of pharmaceutical process development experience.
  • Deep understanding of synthetic organic chemistry and reaction mechanisms.
  • Proven scientific impact through publications, patents, or presentations.
  • Strong communication skills with collaborative leadership in cross-functional teams.
  • Experience in development from preclinical to commercial stages.
  • Familiarity with GMP operations and regulatory submissions.

Responsibilities

  • Lead technical teams in designing and executing laboratory experiments for process optimization.
  • Develop scalable processes ensuring safety and robustness for different program stages.
  • Author patents, publications, and regulatory documents for compliance.
  • Apply modern synthetic chemistry techniques to accelerate development timelines.
  • Communicate effectively with project teams and leadership about strategies and solutions.
  • Mentor junior staff and promote an inclusive, collaborative work environment.
  • Oversee technology transfer and partner interactions for external development.

Benefits

  • 401(k) plan with matching contributions and additional retirement savings.
  • Paid vacation, holidays, and personal days.
  • Paid caregiver/parental and medical leave.
  • Comprehensive health benefits including medical, dental, and vision coverage.
  • Relocation assistance may be available based on business needs.
Full Job Description

ROLE SUMMARY:

  • Lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale‑up.

  • Develop fit‑for‑purpose processes for early‑ and late‑stage programs, ensuring safety, robustness, and scalability.

  • Lead authorship of patents, publications, and regulatory documents.

  • Apply modern synthetic organic chemistry principles, high‑throughput experimentation, mechanistic insight, and data‑rich methods to accelerate development.

  • Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.

  • Drive alignment to project timelines and portfolio strategy.

  • Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment.

  • Lead technology transfer and partner interactions to enable external development campaigns.

  • Build strong stakeholder relationships across process chemistry, partner functions, and project teams.

  • Maintain an external technical presence through publications and presentations.

BASIC QUALIFICATIONS:

  • PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale‑up, and GMP manufacturing

  • Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies.

  • Demonstrated scientific impact via peer‑reviewed publications, patents, or conference presentations.

  • Strong communication skills with demonstrated collaborative leadership in cross functional process development teams.

  • Experience supporting development from preclinical through commercial stages.

  • Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.

PREFERRED QUALIFICATIONS:

  • Proficient in current Good Manufacturing Practices (GMP)

  • Skilled in reaction modeling, material property prediction, and simulation using advanced computational tools such as DynoChem, gPROMS, Visimix, Aspen, Fluent, and Cosmotherm

  • Experience in regulatory filing and compliance

  • Experience developing drug‑linkers for ADCs, PROTACS, DACs or other targeted mixed‑modality therapeutics.

  • Experience mentoring and developing scientific staff.

  • Experience with technology transfer and oversight of external development work.

  • Experience at innovator pharmaceutical companies is strongly preferred.


Additional Job Details:

  • Work Location Assignment: On Premise

  • Last date to apply is June 25, 2026

The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Research and Development

About Pfizer

Hospira, Inc. is the provider of injectable drugs and infusion technologies. Through its broad, integrated portfolio, Hospira is uniquely positioned to Advance Wellness™ by improving patient and caregiver safety while reducing healthcare costs. The company is headquartered in Lake Forest, Ill., and has approximately 16,000 employees.

Pfizer Careers

Joining Pfizer’s global team offers more than just job opportunities; it’s a chance to be a part of a company that leads with science and innovates for better health. As a leading biopharmaceutical company, Pfizer is at the forefront of transforming lives through innovation, leadership, and diversity. Work You’ll Do At Pfizer, you will collaborate with some of the brightest minds in the industry, engaging in work that enhances global health and saves lives. Our culture thrives on intellectual curiosity, professional growth, and inclusivity, making every day a learning opportunity. Here, your skills will be honed, your professional acumen will be expanded, and you will be part of a team that values the power of diverse insights to drive success. Pfizer’s Leadership and Growth Lead and innovate with Pfizer, where we value the growth of each employee. Our leadership is committed to providing employees with the training and resources needed to excel in their careers. Pfizer offers a variety of career paths, including roles in research, marketing, finance, technology, and more, each offering a unique blend of challenges and rewards. Internship and Employment Opportunities Start your career with Pfizer through our internship programs or dive straight into a full-time position. We are hiring individuals who are passionate about healthcare and who seek to make a difference in the world. Our internships provide invaluable industry experience, networking opportunities, and a potential pathway to full-time employment. Benefits and Culture Pfizer is dedicated to fostering a workplace where all employees feel valued and can achieve their full potential. We offer competitive benefits packages that support the health, well-being, and financial security of our employees and their families. At Pfizer, you’ll find a culture that encourages collaboration, innovation, and continuous learning. Join Our Team Explore the numerous job opportunities at Pfizer by searching open positions that match your skills and interests. We look for driven, curious, and innovative team players who are ready to advance their careers in a transformative company. Stay Connected Keep up to date with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here. Personalize your subscription to receive job alerts, latest news, and insider tips tailored to your preferences. Discover the exciting and rewarding career opportunities that await at Pfizer. Interview and Resume Tips Prepare for your future with Pfizer by utilizing our resources for resume building and interview preparation. We provide guidance on how to effectively showcase your skills and experiences to align with the needs of a position at Pfizer. Our goal is to help you succeed in securing a role that suits your professional goals and personal growth aspirations. Pfizer: A Place Where You Can Make a Difference Every position at Pfizer contributes to our mission of making the world a healthier place. Whether through direct patient care, research innovation, or corporate roles that support our operations, your work will have global impact. Join us in our journey to change lives—explore Pfizer careers today.
Learn more about Pfizer
Size
79,000 employees
Market Cap
$285.9 billion
Industry
Net Income
$9.6 billion
Founded
1849
5 Year Trend
+9%
Revenue
$41.9 billion
NASDAQ

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