Senior Platform Engineer

Orchestra Bio, Inc

$130K — $180K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • 5+ years of platform/infrastructure engineering or SRE experience
  • Strong expertise in cloud infrastructure (AWS/GCP/Azure) and IaC tools (Terraform, CloudFormation)
  • Hands-on experience with monitoring and observability systems
  • Experience with CI/CD pipeline design and maintenance
  • Collaborative mindset with proven track record in fast-paced teams

Responsibilities

  • Design and maintain cloud infrastructure for biotech companies
  • Build systems for managing sensitive scientific data and complex financial models
  • Create infrastructure for AI-driven data extraction from operational inputs
  • Establish CI/CD pipelines and monitoring systems to enhance developer experience
  • Ensure compliance with security standards like SOC 2

Benefits

  • Opportunity to work with cutting-edge AI and cloud technology
  • Be part of a mission-driven company focused on improving human health
  • Collaborative and fast-paced startup environment
  • Ability to shape technical and operational practices
  • Work on complex, high-impact projects in biotech
Full Job Description
The Role

We're seeking a Senior Platform Engineer to join our growing team in San Francisco. You'll build and maintain the foundational infrastructure that powers Orchestra's intelligent R&D management platform, ensuring our systems can scale reliably as we help more companies bring breakthrough innovations to market.

Challenges You'll Tackle

Mission Critical Infrastructure: Design and maintain the cloud infrastructure that biotech companies depend on for managing billion dollar R&D programs. Build systems that handle sensitive scientific data, complex financial modeling, and AI workloads with the reliability and security these high stakes operations demand.

Scalable AI Operations: Create the platform infrastructure that powers our AI driven signals extraction from meeting transcripts, documents, and operational data. Design systems that can process unstructured data at scale while maintaining performance and cost efficiency as our customer base grows.

Developer Experience: Create tooling and infrastructure that enables our engineering team to ship features rapidly and reliably. Design CI/CD pipelines, monitoring systems, and development environments that help us maintain quality while moving at startup speed.

Security & Compliance: Implement infrastructure that meets the stringent requirements of biotech and pharmaceutical companies. Build towards SOC 2 compliance while maintaining the development velocity needed in a fast-growing startup environment.

What Sets You Apart

Complexity: You understand how to build platform infrastructure for complex, data-intensive applications where reliability directly impacts scientific outcomes. You're excited about the technical challenges of supporting AI workloads, financial modeling, and secure data processing at scale.

Curiosity: You're genuinely curious about how breakthrough products are developed and excited about building infrastructure that helps scientific organizations operate more effectively. You want your platform work to contribute to bringing medicines and other innovations to market.

Agency: You're drawn to environments where you can shape both the technical infrastructure and operational practices. You enjoy the responsibility of building foundational systems that will scale, balancing the speed needed at an early stage company with the reliability required for mission critical software.

Qualifications

Required
  • 5+ years of platform/infrastructure engineering or SRE experience
  • Strong expertise in cloud infrastructure (AWS/GCP/Azure) including IaC tools (Terraform, CloudFormation)
  • Hands-on experience with monitoring and observability, implementing and running alerting systems and incident response
  • Hands-on experience with CI/CD pipeline design, implementation and maintenance
  • Collaborative mindset with proven track record of working effectively in small, fast-moving engineering teams


Preferred
  • SOC 2 compliance implementation experience: security controls, monitoring, audit preparation
  • Performance optimization experience for data intensive applications
  • AI-assisted development proficiency; leveraging tools to accelerate infrastructure work

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  • Senior Platform Engineer
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    San Francisco, CA 94112 (San Francisco County)
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