Job Description

General Summary:

Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA to lead the Materials Development Group. The Material Science Senior Director will support Vertex's drug development programs through a specialized depth and breadth of knowledge of various relationships between materials properties, pharmaceutical processing conditions, and final product performance and quality attributes. The successful candidate will have a proven track record of applying specialized knowledge in solid state science and engineering principles and be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates.

Key Duties and Responsibilities:

• Lead a team responsible to:
  • Design experiments to discover and characterize all aspects of solid form discovery and development (stable form identification, polymorphism, salts, co-crystals, amorphous material, etc.) for pharmaceutical solid-state materials
  • Design, validate, and implement advanced characterization techniques and predictive models which connect material properties, pharmaceutical processing conditions, and final product performance in the interest of process development and streamlining formulation design
• Leverage knowledge of physiochemical and biopharmaceutical properties of drug substances to influence in vitro and/or in vivo studies that resolve issues related to drug discovery and formulation development.
• Decipher pharmacokinetic data and be accountable for nominating the most appropriate API polymorph across all phases of development.
• Drive project activities and scientific strategies (including at external CROs)
• Potentially lead projects, representing all aspects of pharmaceutical sciences
• Drive innovation and explore new scientific projects and/or business initiatives for company consideration
• Be vested in developing team members and technically mentoring junior-level scientists
• Work in a fast-paced environment with the ability to track multiple assets at a time and make decisions based on limited and evolving data.
• Build a strong network internally and externally to ensure visibility in the field by participation in scientific meetings and/or publishing high quality work
• Influence the strategic direction of the Materials Development Group and the Engineering and Materials Science department
• Use excellent communication and interpersonal skills to influence stakeholders and interact, lead, and collaborate within an interdisciplinary team comprised of chemical engineers, organic, physical, and analytical chemists, materials and solid-state scientists, and formulation development personnel

Knowledge and Skills:

• Experience leading a team of scientists and engineers for materials discovery in the pharmaceutical domain
• Advanced knowledge of solid form discovery, development, and characterization of APIs, inclusive of computational modeling application, from GLP Tox through to commercial
• Accountability for polymorph selection
• Knowledge of pharmacokinetic principles
• Experience with process development and problem solving in a matrix environment
• Strong communication skills and the ability to influence both stakeholders and team members

Education and Experience:

• A BS (+ 20 years), MS (+ 15 years) or PhD (+ 11 years) in Materials Science/Chemistry, or a closely related field, with relevant pharmaceutical materials development experience
• 5 years experience managing a team

#LI-BS1

Pay Range:
$217,900 - $326,900

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite