What You Will Contribute To AltosThe Mass Spectrometry Hub sits within the Institute of Technology, where we have access to an array of cutting edge instrumentation. Together we are a team with a wide variety of skills and experiences that tackle exciting challenges across all of Altos. The Scientist / Senior Scientist, Metabolomics Group Lead is responsible for end-to-end management of metabolomics and lipidomics projects, from experimental design through sample preparation, measurement, data processing and data delivery. This role partners cross-functionally with scientific and bioinformatics teams to ensure robust, reproducible data generation, maintain operational excellence of LC-MS platforms, and drive projects to successful and timely completion.
Responsibilities- Collaborate with cross-functional scientists to define project objectives, assess feasibility, and establish clear deliverables and timelines
- Execute and supervise sample preparation workflows for steady-state metabolomics and lipidomics
- Operate, maintain, and troubleshoot LC-MS instrumentation (e.g., Thermo Exploris 240, SCIEX 7500, Vanquish HPLC) to ensure optimal performance and minimal downtime
- Optimize and adapt extraction protocols to support analysis of diverse and challenging biological samples
- Process and analyze raw datasets with software (e.g. Skyline, Compound Discoverer), and coordinate with bioinformatics teams to ensure accurate data processing, quality control, and efficient project execution
- Maintain accurate and up-to-date project tracking and documentation in systems, such as Benchling, and shared project management tools
- Communicate project status, timelines, and risks effectively to internal stakeholders and leadership
Who You AreMinimum Qualifications- PhD (or equivalent experience) in metabolomics, lipidomics, analytical chemistry, biochemistry, or a related discipline.
- >6 years of hands-on experience with both HRAM and LRMS preferably with Orbitrap Exploris and SCIEX triple quadrupole mass spectrometry platforms.
- Strong experimental design and problem-solving skills, with experience performing sample preparation of cells, tissues, and biofluids.
- Demonstrated experience with mentoring and project management, including managing collaborations with scientists with diverse training backgrounds
Ideal candidates would satisfy two or more of the following preferred qualifications- Experience developing new methods for analysis of metabolites/lipids of interest
- Prior experience in Metabolite Identification and trapping in the context of drug metabolism
- Experience performing large-scale discovery studies of > 1,000 samples
- Experience designing and interpreting complex isotope tracing experiments (e.g., metabolic flux analysis)
- Experience integrating metabolomics/lipidomics with other omics, including proteomics and transcriptomics
Salary Range: Redwood City, California
Scientist II: $156,800- $201,000
Senior Scientist : $172,400- $221,000
This is an on- site role
