GeneFab is seeking an experienced Downstream Process Development Scientist/Lead focused on viral vector purification (AAV and Lentiviral) for in vivo gene therapy. It is a technical, project-based role within a CRDMO environment that balances hands-on process optimization with cross-functional leadership and client-facing responsibilities.
Responsibilities- Design, optimize, and scale-up downstream processes for the purification of viral
vectors, with a focus on in vivo gene therapy products and lentiviral vectors. - Execute experimental plans, analyze data, and provide insightful
recommendations to improve process efficiency, yield, and product quality. - Collaborate with cross-functional teams, including Upstream Process
Development, Analytical Development, and Manufacturing, to ensure seamless
integration of processes. - Troubleshoot and resolve technical challenges in downstream processes, ensuring
robust and scalable solutions. - Present internally and to client with project status updates
- Stay abreast of industry trends, emerging technologies, and regulatory guidelines
to contribute to the continuous improvement of processes and compliance. - Provide direction and leadership to development associates as the team expands.
Qualifications- Ph.D. or Master's degree in Chemical Engineering, Biochemical Engineering,
Biotechnology, or related field with a minimum of 3 years (Ph.D.) or 5 years
(Master's) of relevant industry experience - Proven expertise in downstream process development for viral vectors, with a
focus on AAV and lentiviral vectors. - Hands-on experience with chromatography, filtration, TFF and other downstream
processing techniques. - Strong analytical and problem-solving skills, with the ability to interpret complex
data sets. - Excellent communication skills and the ability to work collaboratively in a team
environment. - Knowledge of regulatory requirements and quality standards related to
biopharmaceutical manufacturing. - Experience with formulation science preferred
$130,000 - $150,000 a year
