Career CategoryOperations
Job DescriptionProcess Development Sr ScientistWhat you will doLet's do this. Let's change the world. In this vital role you will define the favorable quality characteristics of the therapies it produces and optimizes state-of-the-art analytical tools to guide that development. The Pivotal PD organizations focus is developing and commercializing robust manufacturing processes across a wide range of therapeutic modalities, including (but not limited to) monoclonal and bispecific antibodies, bispecific T-cell engagers ("BiTEs"), live oncolytic viruses, and synthetic medicines.
• Identifying and characterizing attributes of therapeutic proteins and synthetic molecules using advanced analytical techniques
• Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography, electrophoresis, and/ or mass spectrometry (LC-MS/MS)
• Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others
• Work in an analytical group equipped with a variety of chromatographic and electrophoretic systems and mass spectrometry platforms
• Communicate (verbal and in written) scientific concepts and results
• Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings
• Work collaboratively with other scientists on multidisciplinary teams
• Work independently in advancing projects and studies within required deadlines
• Actively create or contribute to patent and publications
• Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.
Basic Qualifications:Doctorate degree
OR
Master's degree and 2 years of
Scientific experience
OR
Bachelor's degree and 4 years of
Scientific experience
Preferred Qualifications:• Ph.D. in Analytical Chemistry, Biochemistry with emphasis in mass spectrometry, chromatography, electrophoresis, or other analytical technique
• 2 or more year's post-PhD experience in the pharmaceutical or biotech industry in process and product development and drug substance and drug product analytical method development
• Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantification of chemical modifications
• Training and experience of operating Thermo Q-Exactive mass spectrometers, Agilent mass spectrometers, and Agilent and Waters HPLCs and UHPLCs and associated data processing software (including empower, chromeleon, biopharmafinder, mass hunter, etc.)
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
• Knowledge of statistical processing of data, including related software like Excel, Spotfire & JMP
• Knowledge of programming using R, Python, C++, or machine learning languages
• Experience with automation, robotics, or liquid handlers
• Demonstrated proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, self-starter and team player with strong leadership and decision-making skills capable of providing mentorship to junior staff
What you can expect from usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
SponsorshipSponsorship for this role is not guaranteed.
Salary Range126,066.05USD -170,559.95 USD
