About the Role:
We're looking for a Senior Scientist, Bioinformatics on the Analytical Development team to help us expand what's possible for patients with serious diseases. Reporting to the Senior Scientist, Analytical Development, you'll lead and deliver bioinformatics solutions across Insmed Gene Therapy's discovery and development programs. You will play a critical role in supporting Insmed Gene Therapy's drug discovery and development pipeline by applying computational and statistical approaches to analyze complex biological datasets. You will contribute to and lead efforts to develop tools, build analytical pipelines, perform in-depth data analysis and data modeling to support the wider science team.

What You'll Do:

In this role, you'll have the opportunity to collaborate closely with cross-functional teams spanning biology, chemistry, genetics, translational medicine, clinical development, platform development, and data science. You'll also:

• Design, develop, and maintain bioinformatics pipelines for the analysis of next-generation sequencing (NGS) data including whole-genome sequencing (WGS), whole-exome sequencing (WES), transcriptomics (bulk, single cell and spatial) and epigenomics
• Analyze data and develop interpretation reports for all facets of our drug products including comparability studies, AAV characterization studies and potency cell line characterization
• Collaborate with R&D to develop bioinformatics platforms to help identify and validate molecular biomarkers associated with disease mechanisms, patient stratification, and therapeutic response in rare disease indications
• Provide analytical and statistical rigor to empower better decision making during experimental design and result interpretation
• Present findings clearly to both technical and non-technical stakeholders; contribute to scientific publications, regulatory submissions, and internal reports
• Participate in cross-disciplinary mentoring and training of associate scientists.
• Promote data integrity by employing current Insmed best practices for data handling and storage, to empower broadscale analyses
• Manage code and result documentation using Git and GMP aligned methods to maintain accurate project history, ensure clear team collaboration and GMP data integrity
• Organize and lead projects independently, including presenting project updates to key decision makers
• Work as a key representative in Insmed's Bioinformatics & Data Science group, building collaboratively and working in partnership with members across the organization
• Support qualification and validation activities for bioinformatics pipelines and systems

Who You Are:

You have a PhD along with 5+ years of industry experience OR a Master's and 6 years of industry experience or a Bachelor's and 8 years of industry experience.

You are or you also have:

• Experience working with and analyzing NGS data (PacBio and Element Biosciences)
• In-depth understanding of statistics (Bayesian) and their application across a range of data types
• Experience coding collaboratively and using Git as part of a larger collaborative project
• Experience delivering production-quality code in Python, R, JavaScript, Go, Rust
• Experience with a python testing framework (e.g. pytest, unittest)
• Experience developing tools within a cloud environment (gcloud, AWS, Azure)
• Experience with building and deploying containerized code (Docker)
• Experience with workflow management systems (e.g., Snakemake, Nextflow, CWL)

Nice to have (but not required):

• Degree in bioinformatics, computational biology, genomics, molecular biology or a similar area
• Experience developing and releasing software for use by others
• Experience working with structured data and SQL databases
• Familiarity with popular machine learning algorithms
• Experience with single-cell and/or spatial sequencing analysis (e.g., Seurat, Scanpy)
• Knowledge of regulatory requirements for bioinformatics in drug development (FDA, EMA guidelines)
• Familiarity with FAIR data principles and bioinformatics data standards
• Familiarity with GAMP5 framework and risk-based software validation approaches

Where You'll Work

This is a fully remote role. It can be performed effectively from anywhere while staying connected to your Insmed team and community. Occasional travel for team meetings or events will be expected.

Travel Requirements

This role requires occasional domestic/international travel (approximately 0%-15%).

#LI-REMOTE

#LI-MC1

Pay Range:
$127,000.00-165,500.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.