Principal Scientist Oligonucleotide Process Development (Billerica MA)

Merck Group • $192K — $193K *
Billerica, MA 01821In-Person
Pharmaceuticals & Biotech
8 - 10 years of experience
1 month ago
Job Overview by Ladders

Qualifications

  • PhD in Oligonucleotide Chemistry with 8+ years of industry experience in drug discovery/process development.
  • Proficient in oligonucleotide synthesis, including ASOs and siRNAs, and experience with related modalities.
  • Strong laboratory skills in synthesis, purification, and characterization of Antibody-Oligo conjugates.
  • Expertise in analytical techniques such as UPLC, HPLC, LC-MS, and NMR.
  • Familiarity with DoE (Design of Experiments) and QbD (Quality by Design) principles.

Responsibilities

  • Lead the development and improvement of process strategies for oligonucleotide synthesis.
  • Identify enhancements for yield, purity, and cost-effectiveness in production processes.
  • Collaborate with internal teams and external CROs to solve drug design challenges.
  • Track project timelines and update management on progress and issues.
  • Present and analyze data in line with current scientific literature and methodologies.

Benefits

  • Health insurance coverage.
  • Paid time off (PTO).
  • Retirement contributions for future financial security.
  • Additional perquisites and benefits as outlined in company policy.
Full Job Description
Your Role:
  • Lead process development and synthesis strategies of ASOs, siRNAs and other synthetic modalities. (100 mg-5 g scale). Identify process improvements for better yield, purity, turnaround times and lower cost of goods
  • Experience with a variety of Oligonucleotide modalities (siRNAs, ASOs) and producing Lipids, Dyes, peptides and antibody conjugates.
  • Strong laboratory skills in synthesis, purification, and characterization of Antibody-Oligo conjugate are preferred.
  • Ability to analyze, interpret, and present data are a prerequisite current with scientific literature and understanding of the state of the art in oligonucleotide chemistry, purification, and screening strategies. Expertise in state-of-the-art analytical techniques such as UPLC, HPLC, LC-MS and NMR.
  • Work with both internal chemistry team and external CRO's to generate innovative solutions to synthetic and drug design challenges within the context of oligonucleotide drug discovery projects.
  • Experience with DoE and QbD (Quality by design principles).
  • Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.


Who You Are

Minimum Qualifications:
  • PhD in Oligonucleotide Chemistry and relevant experience in a drug discovery/Process development environment with at least 8 years of oligonucleotide synthesis experience in industry.


Preferred Qualifications:
  • Hand on experience on Akta Synth and OP-100 to modify the protocols and strong familiarity with Unicorn software.
  • Excellent project/time management, and problem-solving skills.
  • Strong communication and people skills and the ability to thrive in a team and goal driven environment
  • Proven track record of scientific contributions in oligonucleotide and conjugates research as evidenced by publications/presentations/patent applications and/or the identification of preclinical development candidates.

Location: Billerica MA

Pay Range for this position: $192,000 - $193,400

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.

About Merck Group

Merck Group Careers

There has never been a more opportune time to join Merck Group, a leading science and technology company in healthcare, life science, and performance materials. Merck Group offers a plethora of job opportunities that cater to a variety of skills and professional aspirations, making it an ideal environment for both seasoned experts and those at the start of their career journey.

Work You’ll Do

At Merck Group, every team member contributes to breakthrough innovations in healthcare, life sciences, and electronics. The company's commitment to diversity and innovation fuels its leadership in various sectors, driving growth and transformation globally. Merck Group’s career paths are diverse, offering positions that challenge individuals to use their skills in new ways every day, supported by robust training programs and development opportunities.

Explore Job Opportunities and Growth

Merck Group is not just about jobs; it's about building a career. With a vast array of positions, from research and development to marketing and sales, the company is keen on hiring and nurturing talent to lead industry transformation. Merck Group’s dedication to professional growth is evident in its comprehensive benefits package and performance management processes that aim to maximize individual potential.

Internship Programs

Starting with an internship at Merck Group can be a pivotal step in securing a prosperous career. Interns gain invaluable industry experience, working alongside seasoned professionals and engaging in projects that offer real-world applications of their studies. Internships often lead to full-time employment opportunities, providing a seamless transition from education to professional employment.

Inclusive Culture and Leadership

Merck Group is proud of its inclusive culture that embraces diversity and fosters an environment where all employees can thrive. The company’s leadership is committed to creating a workplace where diverse ideas lead to innovative outcomes. Merck Group also offers diversity training to ensure all team members are equipped to contribute to the company’s inclusive goals.

Networking and Professional Development

Employees at Merck Group are encouraged to engage in networking and professional development activities that enhance their career trajectories. The company hosts various networking events, workshops, and seminars that are designed to hone skills and foster connections within the industry. Leadership development programs are also a cornerstone, preparing employees for future roles of increased responsibility.

Stay Connected with Merck Group Careers

Interested candidates can explore open positions that match their skills and interests through the Merck Group careers page. The company values curious, creative, and solution-driven team players who are eager to make an impact.

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Industry
Pharmaceuticals & Biotech
* Ladders Estimates

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