Principal Scientist to join our
Biotherapeutics group focused on designing and advancing first-in-class immune-engaging biologics. If you're a protein engineer with
expertise in computational protein design with experimental experience in protein discovery and optimization through antibody display technologies with an interest in advancing drug candidate toward first-in-patient evaluation, this role offers real opportunity, purpose, and scientific challenge.
What You'll Work on- Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based de novo sequence discovery
- Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization.
- Optimize developability in lead optimization through computational and biophysical insights
- Expand company computational protein design tools and capabilities
- Collaborate across functional teams to support candidate selection and preclinical development
- Present findings in a clear, compelling way to multidisciplinary teams
- Mentor junior scientists and help shape our growing discovery efforts
What You Bring - PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field with 5+ years of antibody and biotherapeutic engineering industry experience
- Foundation in protein design and molecular modeling using AI/ML
- Yeast or alternative antibody display technologies experience from design through screening
- Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization
- Strong communication, data interpretation, and cross-functional collaboration skills
What You'll Gain - A hands-on, high-impact role shaping the design of next-generation immunotherapies
- Opportunity to see your work move rapidly from concept to clinic
- A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation
- A chance to collaborate across disciplines and influence key program decisions
- Professional growth through exposure to diverse scientific challenges and cross-functional projects
- Optional mentorship opportunities and the ability to help shape a growing discovery organization
- A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence
- A supportive, open culture built on collaboration, trust, and shared purpose
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Direct impact: Your science will influence platform design and shape next-generation clinical programs.
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Cutting-edge science: Help pioneer new approaches to T cell redirection in solid tumors.
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Personal growth: Gain exposure to every stage of early discovery in a collaborative biotech setting.
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Collaborative culture: Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes.
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Top-tier facilities: Work in a brand-new, purpose-built lab and office space near New Haven, CT.
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Mission with meaning: Join a company working to give more patients real hope in the fight against cancer.
Additional Info • This is a full-time, onsite position based in Branford, CT
• EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered
• We offer competitive salary, benefits, equity, and paid time off
• Learn more about our science and our team at www.evolveimmune.com
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