Job Function: Career Programs
Job Sub Function: Post Doc - Drug Discovery & Pre-Clinical/Clinical Development
Job Category:Career Program
All Job Posting Locations:San Diego, California, United States of America
Job Description:Johnson & Johnson Innovative Medicine R&D is recruiting for a Postdoctoral Scholar, Cell and Genetic Medicine located in San Diego, CA.
Fixed-Term role - Ineligibility for severance
The Postdoctoral Scholar will focus on advancing Lipid Nanoparticle (LNP)-based nucleic acid delivery and genome engineering approaches for next-generation cell and gene therapy applications. This individual will design and execute in vitro assays, evaluate delivery efficiency and nuclear delivery in relevant cellular models, and contribute to LNP formulation and targeted delivery strategies. Collaborate across cross-functional teams to advance research spanning molecular delivery and genome engineering in a dynamic, multidisciplinary research environment.
Principal Responsibilities:
- Independently design, execute, and optimize in vitro assays to assess LNP-mediated nucleic acid tolerability, delivery and nuclear localization in relevant cellular models, including primary immune cells.
- Support the molecular design and evaluation of approaches to improve nuclear uptake, leveraging expertise in molecular and cellular biology as well as nucleic acid biochemistry or related fields.
- Analyze and interpret experimental data with scientific rigor, ensuring reproducibility and data quality.
Contribute to lipid nanoparticle (LNP) formulation and optimization efforts, including formulation workflows and analytical characterization. - Actively advance and apply LNP and analytical techniques within the project scope.
- Support development of bioconjugation strategies and related analytical methods for targeted LNP delivery applications.
- Partner with cross-functional teams to advance project goals.
- Develop a scientific and technical skillset through project assignments, advanced training, conferences, internal meetings, and symposia in relevant areas.
- Develop in-depth knowledge of the organization's drug discovery and preclinical/clinical development processes, programs, policies, and scientific approaches within a multidisciplinary pharmaceutical research environment.
This postdoctoral research position will require full-time, on-site work in a BSL-2 laboratory environment. It is designed to provide advanced scientific training, exposure to drug discovery and pre-clinical development processes, and opportunities to contribute to innovative research in non-viral nucleic acid delivery and genome engineering for cell and gene therapy applications.
Qualifications:
- A minimum of a Ph.D. in Molecular Biology, Cell Biology, Chemical Biology, Biochemistry, Bioengineering, Biophysics, Pharmaceutical Sciences, or related discipline is required.
- Strong foundation in molecular biology and nucleic acid biochemistry, genome editing, or related molecular systems is required.
- Demonstrated experience in in vitro assay development and cellular experimentation is required.
- Experience working with mammalian cell systems is required.
- Demonstrated interest in expanding into nanoparticle delivery systems (e.g., LNPs) and associated analytical techniques is required.
- Prior exposure to lipid nanoparticle (LNP) formulation, nucleic acid delivery systems, or nanoparticle characterization is preferred.
- Familiarity with analytical techniques relevant to nanoparticle systems (e.g., size, encapsulation, or physicochemical characterization) is preferred.
- Experience with HPLC or related analytical methods is preferred.
- Experience with bioconjugation or targeted delivery approaches is preferred.
- Knowledge of CRISPR-based genome editing or targeted integration workflows is preferred.
- Proven ability to independently design and execute experiments with minimal supervision and limited hands-on training is required.
- Must have excellent communication and interpersonal skills.
- Must have creative problem-solving skills.
- Must have strong data analysis and experimental design skills.
- Must have a high level of self-motivation, ownership, and scientific rigor in a research environment.
Required Skills:Preferred Skills:The anticipated base pay range for this position is :$79,000.00 - $127,650.00
Additional Description for Pay Transparency:
Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).
This position is eligible to participate in the Company's long-term incentive program.
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
Vacation -120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado -48 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year
Holiday pay, including Floating Holidays -13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave - 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave - 80 hours in a 52-week rolling period10 days
Volunteer Leave - 32 hours per calendar year
Military Spouse Time-Off - 80 hours per calendar year
For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits
