Eurofins Lancaster Laboratories

Oligonucleotide Senior Scientist

Eurofins Lancaster Laboratories • $95K — $115K *
Louisville, KY 40214In-Person
Pharmaceuticals & Biotech
5 - 7 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Ph.D. or Master's degree in Organic Chemistry or related field required
  • Minimum 5 years of industrial experience in chemical synthesis
  • Hands-on experience with solid-phase oligonucleotide synthesis
  • Experience in oligonucleotide purification process development
  • Strong analytical skills (HPLC, LC-MS)
  • Experience scaling processes to manufacturing
  • Familiarity with automated DNA/RNA synthesizers preferred
  • Knowledge of modified nucleotides preferred
  • Experience in high-throughput oligo production preferred

Responsibilities

  • Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
  • Oversee process development and scale-up from R&D to manufacturing
  • Develop and improve oligonucleotide purification processes like HPLC and ion-exchange
  • Troubleshoot synthesis and purification challenges to enhance yield and purity
  • Collaborate with manufacturing, QC, and engineering for smooth process transfer
  • Evaluate new chemistries and technologies to enhance production
  • Author SOPs, batch records, and technical reports
  • Ensure compliance with quality systems and regulatory standards
  • Mentor lab technicians

Benefits

  • Comprehensive medical coverage
  • Dental and vision options
  • Life and disability insurance
  • 401(k) with company match
  • Paid vacation and holidays
Full Job Description
Oligonucleotide Senior Scientist Include but are not Limited to the Following:

We are seeking a highly skilled and motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.
  • Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
  • Process development and scale-up from R&D to manufacturing
  • Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)
  • Troubleshoot synthesis and purification challenges to improve yield and purity
  • Collaborate with manufacturing, QC, and engineering for process transfer
  • Evaluate new chemistries and technologies
  • Author SOPs, batch records, and technical reports
  • Ensure compliance with quality systems
  • Mentor lab technicians


Qualifications

Basic Minimum Education Qualifications:
  • Ph.D. or Master's degree in Organic Chemistry or related field (required)

Basic Minimum Work Requirements:
  • Minimum 5 years of industrial experience in chemical synthesis
  • Hands-on experience with solid-phase oligonucleotide synthesis
  • Hands-on experience in oligonucleotide purification process development
  • Strong analytical skills (HPLC, LC-MS)
  • Experience scaling processes to manufacturing
  • Experience in GMP or regulated environments, preferred
  • Familiarity with automated DNA/RNA synthesizers, strongly preferred
  • Knowledge of modified nucleotides, strongly preferred
  • Experience in high-throughput oligo production, strongly preferred
  • Authorization to work in the United States indefinitely without restriction or sponsorship.

The Ideal Candidates Possess the Following:
  • Fast-paced, collaborative environment
  • Ability to manage multiple priorities
  • Occasional off-hours support as needed


Additional Information

Position is full-time working Monday - Friday 8:00am - 5:00pm, with overtime and weekend work as needed. Candidates currently living within a commutable distance of Louisville, KY are encouraged to apply.
  • Excellent full-time benefits including comprehensive medical coverage, dental, and vision options
  • Life and disability insurance
  • 401(k) with company match
  • Paid vacation and holidays

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About Eurofins Lancaster Laboratories

Eurofins Lancaster Laboratories is a leading contract research organization (CRO) providing analytical, research and testing services to clients in the pharmaceutical, biopharmaceutical, biotechnology, crop protection, chemical, food, environmental and consumer products industries. The company was founded in 1961 and has grown to become one of the largest CROs in the world, with over 50 locations in 20 countries. Eurofins Lancaster Laboratories is part of the Eurofins Scientific Group, a global leader in bioanalytical testing and laboratory services. The company's services include method development and validation, stability testing, quality control testing, and regulatory compliance support.
Learn more about Eurofins Lancaster Laboratories
Size
12,000 employees
Industry
Pharmaceuticals & Biotech
* Ladders Estimates

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