Job Description Summary
As a Postdoctoral Research Fellow, you will join Discovery Sciences team in Cambridge and pursue an innovative research project at the forefront of biomedical science and drug discovery. You will work alongside leading scientists in a highly collaborative, multidisciplinary environment while gaining exposure to the broader ecosystem that translates scientific discovery into medicines.

Job Description

Internal Job Title: Discovery Postdoctoral Fellow

Position Location: Cambridge, MA (Onsite)

* Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you.

* This position is not eligible for visa sponsorship. Please only apply if you are currently authorized to work in the US for the 3 year duration of the program.

* This is a full-time training position of up to three years in duration.

Research Opportunity:

Within your position you will investigate GPCR and cAMP signaling pathways in a multidisciplinary team. GPCR proteins are confirmed key drug targets playing an important role in cAMP linked downstream physiological effects. To gain mechanistic insights into cAMP signaling, you will explore key nodes in these various pathways and their intersections using cellular tools, human genetics, genomics, chemical biology, pharmacology and more.

Start Date:

The start date for the 2026 Novartis BR Postdoctoral Fellowship Program cohort is October, 2026. Please confirm your availability to meet this date in your cover letter.

Key Responsibilities:

As a Discovery Postdoctoral Fellow, you will:

• Shape your postdoc project by dedicating your efforts to multiple possible key scientific questions.
• Combine diverse available tools to consolidate your research strategy (in vitro assays, pharmacological tools, genetic studies, animal models).
• Design, implement and advance scientific experiments to uncover novel mechanisms underlying cAMP-dependent signaling.
• Unravel the interaction of GPCRs with less characterized cAMP pathway nodes and understand mode of action.
• Increase understanding of novel pharmacological target classes either by in depth characterization of single members of questioned pathways or by gaining insights in unexplored general interaction specificities.
• Work independently as well as with interdisciplinary teams and interact with diverse teams covering a broad spectrum of expertise.

Essential Requirements:

• PhD (or equivalent doctoral degree) in a relevant scientific discipline completed prior to the fellowship start date. The program is intended for scientists immediately following their PhD training (PhD conferred in 2026 only).
• Demonstrated record of scientific achievement (publications, presentations, patents, or equivalent)
• Strong commitment to learning, innovation, fundamental exploratory research and professional development
• Basics in cell culture, genetics, developmental biology, molecular biology and biochemistry techniques.
• Excellent analytical, communication, presentation and organizational skills.
• Boundless curiosity

Desirable Requirements:

• Imaging techniques, knowledge in signaling assays, as well as genomics/proteomics analysis workflows would be a plus

How to Apply:

Please submit your CV and cover letter by 09/4/2026. In your cover letter, please describe your research interests, career aspirations, and how participation in the Novartis Biomedical Research Postdoctoral Fellowship Program will support your long-term development.

Compensation & Benefits:

The starting salary for this position is 87,000 USD per year.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

To learn more about the culture, rewards and benefits we offer our people click here.

Salary Range
$57,800.00 - $107,300.00

Skills Desired
Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Curious Mindset, Data Analysis, Detail-Oriented, Ethics, Gene Therapy, Immunology, Machine Learning (ML), Mammalian Cell Culture, Medical Research, Molecular Biology, Patient Care, Science