We are seeking to hire an Associate Scientist to join our Purification Process Development team. The successful candidate will be responsible for supporting late-stage downstream process development activities for our large molecule pipeline.
Key Accountabilities/Core Job Responsibilities:
- Support purification process characterization, validation, PPQ and BLA-enabling activities.
- Monitor process performance, trend data, and coordinate sample handling from GMP manufacturing campaigns.
- Extract and organize data for report and submission authoring and contribute to statistical analysis.
- Support tech transfer for and GMP campaign readiness.
- Execute lab-scale chromatography and filtration studies to inform late-stage data packages.
- Execute in-process testing using ELISA, HPLC, UV and SDS-Page based analytics
- Summarize key experimental data and document all experiments in an electronic lab notebook in a timely manner.
- Collaborate closely with colleagues in CMC, Discovery and other functions to achieve project goals.
Requirements- BS/MS in Biology, Biochemistry, Chemical Engineering or related scientific discipline with 3+ years of industry experience
- Experience in protein characterization, design of experiments and analytics
- Experience monitoring downstream GMP and/or pilot production unit operations
- Hands-on experience with AKTA protein purification systems, lab-scale TFF systems and antibody characterization methods including: HPLC, LC/MS, SDS-PAGE, DLS and other biophysical techniques
- Excellent critical thinking, scientific problem-solving and communication skills
- Prior experience in a late-stage process development setting is preferred
Salary Range: $106,000.00 to $138,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
