Job DescriptionPosition available for a Research Scientist in a neuroscience laboratory (Gandy/Ehrlich) focused on study of neurodegenerative diseases, including Alzheimer's, X-linked dystonia parkinsonism, and Huntington's disease. Applicants should have experience in molecular, cell and/or animal model systems. Experience with informatics is a plus. These projects involve a broad array of well-established techniques, including mouse breeding and genotyping (with assistance from a research associate and outsourcing of genotyping), molecular biology (e.g. CrispR), histology, cell culture including iPSCs, primary cells and cell lines, microdissection of tissues, RNA and protein preparation, and/or other specialized approaches to study neurodegeneration, including a multi-omic approach.
Responsibilities- Conducts research to develop methodologies, instrumentation and procedures for medical application, analyzing data and presenting findings.
- Designs and conducts complex clinical research studies requiring the determination and evaluation of alternative methods, computational modeling, diagnosis and treatment.
- Plans and directs studies to investigate human or animal disease, preventive methods, and treatments for disease.
- May assist in clinical laboratory operations.
- Follows strict safety procedures when handling materials to avoid contamination.
- Teaches principles of medicine and medical and laboratory procedures to physicians, residents, students, and research staff.
- Confers with health departments, industry personnel, physicians, and others to develop health safety standards and public health improvement programs.
- Develops treatments and designs research tools and techniques.
- Explores subject area and defines scope and selection of problems for investigation through conceptually related studies.
- Develops hypotheses to be tested and methodology for evaluating results.
- Examines the results of clinical trials and adjusts the dosage levels to reduce negative side effects or to induce better results.
- Communicates research results to the scientific community via published papers.
- Develops new proposals for research and obtain support for new and/ or continuing research activities.
- Makes recommendations that have a major impact on extensive scientific research activities.
- Performs other related duties.
Qualifications- Ph.D. in Biological Science or related field
- Three years experience
Preferred Skills
- 3-years experience following a PhD in neuroscience, cell biology, pharmacology, immunology, biochemistry, molecular biology, pathology, or related discipline.
- Evidence for independent skills in molecular biology, and standard immunoprotein methods (e.g., immunoblotting, immunoprecipitation, immunohistochemistry, ELISA) required. Experience with mouse handling, husbandry and genotyping essential to work with Research Associates.
- Initially, research a topic chosen by the PI, but input from the person in this position is essential.
- Gather and analyze data.
- Prepare scientific reports, manuscripts including figures, and grant proposals, the latter either independently or assistance of an application from the PI.
