Smith & Nephew is a global medical technology company headquartered in London, England. The company designs, manufactures, and sells medical devices and products for orthopedic reconstruction, sports medicine, and trauma. Smith & Nephew operates in more than 100 countries and employs over 17,500 people worldwide. The company was founded in 1856 by Thomas James Smith and his nephew, Horatio Nelson Smith, and has grown through a series of mergers and acquisitions. Smith & Nephew's products include joint replacement systems, wound care products, and surgical instruments. The company is listed on the London Stock Exchange and is a constituent of the FTSE 100 Index.