Mayo Clinic is a nonprofit academic medical center based in Rochester, Minnesota, focused on integrated clinical practice, education, and research. It employs more than 4,500 physicians and scientists and 58,400 administrative and allied health staff. The practice specializes in treating difficult cases through tertiary care and destination medicine. It is home to the Mayo Clinic College of Medicine and Science, which includes a medical school and research programs. Mayo Clinic has a large presence in three U.S. metropolitan areas: Rochester, Minnesota; Jacksonville, Florida; and Phoenix, Arizona. It also has several affiliated hospitals and clinics elsewhere in the United States and around the world.