Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Software Engineer - Vehicle Health Management
$160K - $217K *
Launch innovative software for embedded systems in military aircraft, guiding full lifecycle development to enhance operational efficiency and safety. Collaborate with multidisciplinary teams to deliv...
Reposted 1 week ago
Senior Software Engineer - Vehicle Health Management
$160K - $217K *
Advance critical software solutions for embedded systems, ensuring performance and compliance across military applications with a focus on lifecycle management and predictive maintenance. Join a dynam...
Reposted 1 week ago
Senior Structural Engineer - Aerospace & Industrial (Kansas City)
$95K - $115K *
Lead structural design teams to deliver innovative solutions across diverse projects, ensuring quality and compliance while managing budgets and client expectations throughout the design and construct...
2 weeks ago
Director of Forward Deployed Engineering
$150K - $180K *
Lead the charge in developing innovative AI-driven solutions by managing a dual-function team of engineers and data scientists, enhancing customer engagements, and optimizing delivery models for impac...
Reposted 3 weeks ago
Senior Partner solution program manager (Financial Reporting, Data Management)
$93K - $165K *
Champion partner implementation readiness by leading global enablement projects, designing scalable training programs, and creating high-quality certification content to empower partners in delivering...
3 weeks ago
Senior Customer Success Manager, Enterprise
$136K - $215K *
Lead the charge in enhancing enterprise customer relationships by managing renewals, identifying risks, and driving engagement strategies. Collaborate across teams to ensure customer value and satisfa...
3 weeks ago
Senior Industrial Engineer, Project Engineering
$98K - $122K *
Unlock potential by leading the design and implementation of innovative warehouse solutions. Collaborate with cross-functional teams to optimize operations, ensuring compliance with safety and quality...
Reposted 1 week ago
Builder Developer II/III/IV (Senior Agentic Software Engineer)
$120K - $145K *
Transform enterprise software development by leveraging AI to create autonomous agents and workflows. Drive modernization of legacy systems with innovative solutions, focusing on automation and archit...
1 week ago
Senior DevOps Engineer - Top Secret
$127K - $172K *
Unlock potential by driving innovative DevOps solutions that enhance software delivery and operational excellence. Collaborate across teams to streamline processes, improve system observability, and e...
2 weeks ago
Principal Process Engineer - API + OSD
$170K - $240K *
Empower your career as a vital contributor solving complex challenges in life sciences. Collaborate with industry leaders, drive innovation, and shape processes from design through production, ensurin...
Reposted 4 weeks ago
Senior Hiring & Internal Mobility Partner (Talent Acquisition)
$90K - $145K *
Engage with us to lead full lifecycle recruiting across diverse functions, ensuring a high-quality candidate experience. Collaborate with hiring managers to adapt strategies and maintain operational e...
Today
Senior Director, Product Management - Developer & AI
$267K - $401K *
Lead the charge in defining product strategy and execution for Developer Experience and AI initiatives, ensuring secure interactions and impactful outcomes across technical domains while collaborating...
4 weeks ago
Senior Data Scientist II, Ranking & Relevance
$183K - $216K *
Innovate the analytical roadmap for ranking and relevance, collaborating with cross-functional teams to enhance user engagement and advertiser outcomes while driving long-term platform economics and s...
2 weeks ago
$86K - $107K *
Lead advanced analytics projects that drive strategic decisions, optimize sales productivity, and enhance operational efficiency. Collaborate with executives to deliver data-driven insights and implem...
3 days ago
Senior Cloud Infrastructure Engineer
$120K - $145K *
Empower innovation by leading the design of scalable Azure cloud solutions. Drive automation, mentor engineers, and leverage AI to enhance infrastructure reliability and operational efficiency while c...
Today
$135K - $160K *
Champion the design and delivery of modern data platforms, focusing on Microsoft Fabric and Azure. Lead client engagements, define architectures, and establish best practices for data solutions across...
Reposted yesterday
$120K - $145K *
Drive impactful program management by leading cross-functional initiatives, ensuring alignment with strategic goals, and delivering measurable results in a dynamic environment. Collaborate effectively...
1 week ago
Senior Strategic Finance Manager
$190K - $214K *
Drive strategic finance initiatives by leading FP&A processes, collaborating with cross-functional teams, and building financial models to evaluate product profitability and investments. Shape the fut...
2 weeks ago
Lead Program Manager, Customer Portfolio
$110K - $130K *
Lead complex product group initiatives, ensuring successful delivery through strategic planning, stakeholder engagement, and cross-team collaboration. Mentor program managers while driving transformat...
3 weeks ago
$163K - $204K *
Partner with us to architect and enhance our next-gen web console, driving frontend infrastructure and user experience across multiple products while ensuring robust security and seamless integration...
Yesterday
Systems Engineer - Design & Development - Hybrid
$124K - $138K *
Transform mission-critical outcomes as a Senior Systems Engineer with expertise in MBSE and digital engineering. Drive program milestones, mentor junior engineers, and lead complex systems engineering...
Reposted yesterday
Principal Cloud Systems Engineer
$131K - $237K *
Join our team as a Principal Cloud Systems Engineer, driving modernization initiatives for the DoD. Leverage your expertise in cloud infrastructure and distributed systems to design secure, innovative...
Yesterday
Lead Digital Product Manager (Workday)
$134K - $209K *
Lead the product strategy and delivery for a comprehensive Workday ecosystem. Manage a team of product managers to enhance HR capabilities, ensuring alignment with enterprise priorities and improving...
6 days ago
$150K - $180K *
Lead the charge in designing a cutting-edge platform for modern data centers, integrating AI and cloud technologies. Collaborate with cross-functional teams to build a robust, scalable architecture th...
6 days ago
Senior Program Manager, Knowledge
$90K - $150K *
Transform global support operations by architecting an AI-driven knowledge strategy. Lead initiatives to enhance internal and external knowledge management, driving efficiency and customer satisfactio...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.