Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Application Development Team Manager
$147K - $198K *
Lead a dynamic software development team, driving modernization and secure engineering practices across legacy and cloud-native systems while fostering collaboration and high-quality delivery...
1 week ago
Senior Machine Learning Engineer, Ads Forecasting & Scenarios
$216K - $303K *
Discover an exciting opportunity to drive innovation in ad optimization and marketplace quality, creating impactful bidding and auction systems that enhance user experience and maximize advertiser suc...
Reposted 5 days ago
Senior Mechanical Engineer | Chiller Systems
$95K - $115K *
Advance your career by developing cutting-edge marine chiller systems. Lead engineering projects, innovate HVAC&R solutions, and collaborate on product design to meet commercial and defense needs whil...
Reposted 1 week ago
Senior Director, Engineering, Precision Defense
$270K - $365K *
Lead a dynamic engineering organization to transform offensive capabilities into proactive defense. Shape strategy, scale teams, and deliver innovative solutions across multiple pillars, ensuring robu...
1 week ago
Senior Project Manager, Client Services
$110K - $130K *
Drive client satisfaction as a Senior Project Manager, overseeing eDiscovery projects, managing budgets, and consulting on best practices. Lead teams, enhance workflows, and ensure timely delivery whi...
1 week ago
Senior Game Application Security Analyst
$177K - $265K *
Join a team that's dedicated to safeguarding player experiences by investigating and combating cheating in games. Leverage your analytical skills to create data-driven reports and collaborate with eng...
Reposted 6 days ago
Solution Consultant, Data Center & Cloud Platform
$110K - $130K *
Unlock potential by joining a dynamic team of Solution Consultants, delivering expert guidance on Atlassian products to help clients maximize their investments and achieve strategic outcomes in the Pu...
3 weeks ago
US LBM Lead Software Engineer - Application Development (Supply Chain)
$110K - $130K *
Optimize technology solutions for supply chain operations by leading full-stack engineering efforts. Drive development, mentor teams, and align projects with business goals to deliver scalable web and...
Reposted 2 weeks ago
$120K - $170K *
Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...
1 week ago
$125K - $150K *
Empower strategic financial decisions by analyzing investments, market opportunities, and capital allocation. Collaborate with C-suite executives to drive growth and optimize resource allocation while...
2 weeks ago
Principal Product Manager, AI Strategy & Execution
$166K - $249K *
Shape the future of AI in healthcare by defining and executing a strategic roadmap that integrates intelligent solutions into clinical workflows, ensuring safety and efficiency while collaborating wit...
4 weeks ago
Sr SW Design Quality Assurance Engineer
$95K - $159K *
Join our team to drive software design assurance for innovative cloud-based and AI/ML systems. Collaborate with cross-functional teams to ensure compliance with global regulations and enhance product...
Yesterday
Senior Project Manager - Accela & Municipal Permitting Systems
$148K - $178K *
Transform municipal services by leading complex projects and optimizing the Accela Civic Platform. Drive innovation in permitting and development processes while ensuring compliance and enhancing cust...
3 weeks ago
Solutions Engineer, Enterprise
$80K - $95K *
Unlock potential by designing and implementing fiber network solutions, collaborating with sales and engineering teams to ensure customer satisfaction and compliance while managing multiple projects i...
4 weeks ago
$77K - $92K *
Unlock potential by collaborating with teams to develop innovative healthcare analytics solutions. Engage in fast-paced projects, implement new technologies, and ensure system accuracy while enhancing...
Today
$150K - $200K *
Transform the security landscape by leading corporate security and compliance initiatives. Own identity infrastructure, manage vendor relationships, and ensure customer trust while implementing robust...
2 weeks ago
$90K - $110K *
Join a team that's dedicated to delivering successful large-scale projects. Oversee all phases from planning to execution, ensuring timely completion and budget adherence while fostering strong custom...
1 week ago
$108K - $130K *
Empower enterprise infrastructures by designing automated workflows for secure, scalable network management. Utilize advanced scripting and automation to optimize systems while leveraging your experti...
Reposted 6 days ago
$150K - $180K *
Transform the future of AI-driven infrastructure products by leading strategic growth initiatives, collaborating closely with Marketing and Engineering, and influencing key product decisions for optim...
Reposted 5 days ago
Senior Manufacturing Engineer (Remote)
$108K - $129K *
Champion innovative manufacturing solutions by leading design feedback, quoting, and DFM initiatives. Collaborate cross-functionally to enhance product manufacturability and mentor engineers, driving...
6 days ago
Advanced Information Technologist – Mid Level Cloud Engineer
$119K - $161K *
Shape your career as a Cloud Engineer by optimizing deployment processes, managing vendor integrations, and ensuring efficient cloud operations across various environments. Drive success through innov...
Reposted 3 days ago
Senior Manager, Data Engineering
$146K - $229K *
Unlock potential by leading a high-accountability engineering team to architect and deliver innovative data products, enabling analytics and AI while fostering a culture of quality and collaboration a...
Today
$107K - $150K *
Join a team that's shaping the future of electrical engineering by leading innovative design projects. You'll guide a talented group in delivering high-quality solutions for complex installations whil...
2 weeks ago
Project Manager 4 (Project Manager/SRE)
$130K - $165K *
Elevate project management excellence by overseeing operations, developing strategic plans, and collaborating with stakeholders to enhance network security and incident response for the VA's enterpris...
Yesterday
$93K - $125K *
Join a dynamic team as a technical resource, enhancing enterprise applications and infrastructure services. Drive operational excellence, support cross-functional initiatives, and ensure reliable, sec...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.