Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$119K - $150K *

Shape the future of enterprise application integrations by leading technical design and implementation for Finance, Accounting, and Supply Chain projects, collaborating with cross-functional teams to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $170K *

Lead the development of innovative data solutions, integrating AI/ML capabilities and optimizing data pipelines within Palantir Foundry and Databricks. Collaborate with cross-functional teams to enhan...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$175K - $190K *

Lead and mentor a team of Program Managers to drive strategic data center builds, ensuring seamless execution and stakeholder alignment while navigating complex infrastructure challenges in a high-gro...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$210K - $256K *

Accelerate progress at a leading consulting firm by managing a large-scale data transformation program. Oversee governance, stakeholder alignment, and change management across multiple workstreams to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$184K - $356K *

Join a team that's pushing the boundaries of AI technology. As a Deep Learning Engineer, you'll integrate advanced CUDA features and optimize frameworks for high-performance AI applications, tackling...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Join a team that's dedicated to enhancing employee experiences globally. Lead HR partnerships, support managers through change, and drive engagement initiatives while managing complex employee relatio...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$69K - $101K *

Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$200K - $250K *

Unlock the potential of Open Source and AI governance by leading a multidisciplinary team to ensure compliance, drive best practices, and foster innovation across the enterprise, while collaborating w...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $200K *

Unlock potential by driving enterprise agent solutions with Microsoft technologies. Collaborate on agent governance, lifecycle management, and secure operations, while translating designs into product...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$160K - $180K *

Transform the future of cloud infrastructure by leading DevOps initiatives, enhancing systems integration, and driving innovative solutions for federal clients. Collaborate with stakeholders to optimi...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$107K - $177K *

Lead innovative grid modernization projects for electric utilities, enhancing distribution systems through advanced engineering solutions. Collaborate with clients and teams to improve reliability, ef...

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$145K - $165K *

Drive your career by owning the end-to-end data platform, designing and maintaining scalable pipelines and infrastructure. Collaborate with analytics teams to ensure data quality and governance while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $181K *

Create impactful technical solutions in military electrification projects. Collaborate with defense clients and provide expertise throughout the proposal process, ensuring compliance and mission effec...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Join a team that's redefining data engineering by building scalable data systems and interfaces. You'll design data models, develop real-world use cases, and ensure reliable data flows, all while writ...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$147K - $198K *

Lead a dynamic software development team, driving modernization and secure engineering practices across legacy and cloud-native systems while fostering collaboration and high-quality delivery...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$216K - $303K *

Discover an exciting opportunity to drive innovation in ad optimization and marketplace quality, creating impactful bidding and auction systems that enhance user experience and maximize advertiser suc...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Media

$95K - $115K *

Advance your career by developing cutting-edge marine chiller systems. Lead engineering projects, innovate HVAC&R solutions, and collaborate on product design to meet commercial and defense needs whil...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$270K - $365K *

Lead a dynamic engineering organization to transform offensive capabilities into proactive defense. Shape strategy, scale teams, and deliver innovative solutions across multiple pillars, ensuring robu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive client satisfaction as a Senior Project Manager, overseeing eDiscovery projects, managing budgets, and consulting on best practices. Lead teams, enhance workflows, and ensure timely delivery whi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$177K - $265K *

Join a team that's dedicated to safeguarding player experiences by investigating and combating cheating in games. Leverage your analytical skills to create data-driven reports and collaborate with eng...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Unlock potential by joining a dynamic team of Solution Consultants, delivering expert guidance on Atlassian products to help clients maximize their investments and achieve strategic outcomes in the Pu...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Optimize technology solutions for supply chain operations by leading full-stack engineering efforts. Drive development, mentor teams, and align projects with business goals to deliver scalable web and...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $170K *

Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Empower strategic financial decisions by analyzing investments, market opportunities, and capital allocation. Collaborate with C-suite executives to drive growth and optimize resource allocation while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$166K - $249K *

Shape the future of AI in healthcare by defining and executing a strategic roadmap that integrates intelligent solutions into clinical workflows, ensuring safety and efficiency while collaborating wit...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.